Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI: a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong Yeon | - |
dc.contributor.author | Kwon, Hyo Jeong | - |
dc.contributor.author | Park, Su Jin | - |
dc.contributor.author | Yoo, Chungkwon | - |
dc.contributor.author | Kim, Yong Yeon | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.date.accessioned | 2021-09-02T21:11:10Z | - |
dc.date.available | 2021-09-02T21:11:10Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0271-3683 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80913 | - |
dc.description.abstract | Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 x 0.98 x 1 mm(3)) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal-Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | LATERAL GENICULATE-NUCLEUS | - |
dc.subject | OPEN-ANGLE GLAUCOMA | - |
dc.subject | VISUAL PATHWAY | - |
dc.subject | HUMAN EYE | - |
dc.subject | MORPHOMETRY | - |
dc.subject | PRESSURE | - |
dc.subject | PARADIGM | - |
dc.subject | DENSITY | - |
dc.subject | ATROPHY | - |
dc.subject | NUMBER | - |
dc.title | Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI: a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Chungkwon | - |
dc.contributor.affiliatedAuthor | Kim, Yong Yeon | - |
dc.identifier.doi | 10.1080/02713683.2017.1399426 | - |
dc.identifier.scopusid | 2-s2.0-85033683089 | - |
dc.identifier.wosid | 000424419400018 | - |
dc.identifier.bibliographicCitation | CURRENT EYE RESEARCH, v.43, no.3, pp.397 - 405 | - |
dc.relation.isPartOf | CURRENT EYE RESEARCH | - |
dc.citation.title | CURRENT EYE RESEARCH | - |
dc.citation.volume | 43 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 397 | - |
dc.citation.endPage | 405 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | LATERAL GENICULATE-NUCLEUS | - |
dc.subject.keywordPlus | OPEN-ANGLE GLAUCOMA | - |
dc.subject.keywordPlus | VISUAL PATHWAY | - |
dc.subject.keywordPlus | HUMAN EYE | - |
dc.subject.keywordPlus | MORPHOMETRY | - |
dc.subject.keywordPlus | PRESSURE | - |
dc.subject.keywordPlus | PARADIGM | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | NUMBER | - |
dc.subject.keywordAuthor | Glaucoma | - |
dc.subject.keywordAuthor | optic nerve head | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | optic-disk cup volume | - |
dc.subject.keywordAuthor | retinal nerve fiber layer thickness | - |
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