Immunogenicity and safety of a split-virion quadrivalent influenza vaccine in adults 18-60years of age in the Republic of Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Won Suk | - |
dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Lee, Jacob | - |
dc.contributor.author | Choi, Jun Yong | - |
dc.contributor.author | Lee, Jin-Soo | - |
dc.contributor.author | Kim, Moo Soo | - |
dc.contributor.author | Kim, Hee Soo | - |
dc.contributor.author | Bang, Joon | - |
dc.contributor.author | Lavis, Nathalie | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.date.accessioned | 2021-09-02T21:11:48Z | - |
dc.date.available | 2021-09-02T21:11:48Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2164-5515 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80919 | - |
dc.description.abstract | VaxigripTetra (R) (Sanofi Pasteur, Lyon, France) is a quadrivalent split-virion inactivated influenza vaccine (IIV4) containing two B-lineage strains approved in the European Union and Taiwan in 2016 for individuals 3years of age. Here, we describe an observer-blind, randomized, controlled, multicenter trial study evaluating the immunogenicity and safety of the Northern Hemisphere 2015-2016 formulations of IIV4 and the licensed split-virion trivalent inactivated influenza vaccine (IIV3) in the Republic of Korea (ClinicalTrials.gov no. NCT02550197). The study included 300 Korean adults 18-60years of age randomized 2:1 to receive a single injection of IIV4 or IIV3. For each of the four vaccine strains in IIV4, 21days after vaccination, geometric mean post-/pre-vaccination ratios of hemagglutination inhibition titers were 3.97. Seroconversion/significant increases rates were 40% for all but the A/H1N1 strain, for which the rate was 39.7%. Results were similar for the three strains in IIV3. For the additional B-lineage strain not in IIV3 (Victoria), hemagglutination inhibition antibody titers were higher for IIV4 than for IIV3. Solicited reactions and adverse events were similar between IIV4 and IIV3, and no serious adverse events or new safety signals were detected. These results confirm the robust immunogenicity and acceptable safety of IIV4 in adults 18-60years of age and show that including a second B-lineage strain should provide broader protection against B-strain influenza without affecting vaccine safety or the immunogenicity of other three vaccine strains. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | CHILDREN | - |
dc.subject | HISTORY | - |
dc.title | Immunogenicity and safety of a split-virion quadrivalent influenza vaccine in adults 18-60years of age in the Republic of Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Won Suk | - |
dc.contributor.affiliatedAuthor | Noh, Ji Yun | - |
dc.contributor.affiliatedAuthor | Kim, Woo Joo | - |
dc.identifier.doi | 10.1080/21645515.2017.1381808 | - |
dc.identifier.scopusid | 2-s2.0-85034250766 | - |
dc.identifier.wosid | 000428053800022 | - |
dc.identifier.bibliographicCitation | HUMAN VACCINES & IMMUNOTHERAPEUTICS, v.14, no.3, pp.587 - 592 | - |
dc.relation.isPartOf | HUMAN VACCINES & IMMUNOTHERAPEUTICS | - |
dc.citation.title | HUMAN VACCINES & IMMUNOTHERAPEUTICS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 587 | - |
dc.citation.endPage | 592 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | HISTORY | - |
dc.subject.keywordAuthor | quadrivalent influenza vaccine | - |
dc.subject.keywordAuthor | inactivated influenza vaccine | - |
dc.subject.keywordAuthor | adults | - |
dc.subject.keywordAuthor | Republic of Korea | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.