Identification of Polygonum orientale constituents using high-performance liquid chromatography high-resolution tandem mass spectrometry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hyeji | - |
dc.contributor.author | Park, Yeeun | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Yan, Xi-Tao | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.date.accessioned | 2021-09-02T21:12:34Z | - |
dc.date.available | 2021-09-02T21:12:34Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80926 | - |
dc.description.abstract | Our primary focus in this research was to identify and characterize its bioactive compounds for potential therapeutic use. Twenty-seven metabolites of Polygonum orientale were identified using LC-QTOF tandem mass spectrometry. Interestingly, P. orientale extracts included several highly oxygenated flavonoids were isolated from P. orientale by column chromatography. C-13 NMR data of highly oxygenated flavonoids (1-7) are reported here for the first time. In addition, nitric oxide, 1,1-diphenyl-2-picrylhydrazyl, and water-soluble tetrazolium salt assays were carried out on the isolated compounds to investigate their anti-inflammatory, anti-oxidant, and neuroprotective activities, respectively. Compounds 1, 2, 3, 5, 7, and 8 significantly attenuated lipopolysaccharide-stimulated NO production in BV2 cells without affecting cell viability. Compounds 9-12 exhibited significant antioxidant activity, while compounds 8, 9, and 12 exhibited protective effects against glutamate-induced neurotoxicity in HT22 cells. Our results indicate that P. orientale is a promising source of natural agents for the potential treatment of inflammation and neurodegenerative diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | VANICOSIDE-B | - |
dc.subject | FLAVONOIDS | - |
dc.subject | CELL | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | GLYCOSIDES | - |
dc.title | Identification of Polygonum orientale constituents using high-performance liquid chromatography high-resolution tandem mass spectrometry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.1080/09168451.2017.1415124 | - |
dc.identifier.scopusid | 2-s2.0-85040809272 | - |
dc.identifier.wosid | 000423629000003 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.82, no.1, pp.15 - 21 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 82 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15 | - |
dc.citation.endPage | 21 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | VANICOSIDE-B | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordAuthor | Polygonum orientale | - |
dc.subject.keywordAuthor | LC-QTOF MS | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | anti-oxidant | - |
dc.subject.keywordAuthor | neuroprotective | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.