Association between Vitamin D level and/or deficiency, and systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-02T21:17:00Z | - |
dc.date.available | 2021-09-02T21:17:00Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/80963 | - |
dc.description.abstract | This study aimed to evaluate the relationship between the level of 25-hydroxyvitamin D [25(OH)D] and systemic lupus erythematosus (SLE). We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and/or deficiency in patients with SLE, compared with that in healthy controls. In total, 18 studies consisting of 1,083 patients with SLE and 1,273 controls were included. Vitamin D level was significantly lower in the SLE group than in the control group (standardized mean difference [SMD] = -0.938, 95% CI = -1.352 to -0.524, p = 9.0 x 10(-6)). Stratification by ethnicity showed a significantly decreased vitamin D level in the SLE group in the European and Arab populations (SMD = -1.485, 95% CI = -2.427 to -0.543, p = 0.002; SMD = -1.067, 95% CI = -1.251 to -0.883, p < 1.0 x 10(-8)), and an association tendency between decreased vitamin D level and SLE in the Asian population (SMD = -0.874, 95% CI = -2.073 to -0.324, p = 0.153). Subgroup analysis by sample size showed a significantly lower vitamin D level in the SLE group in small-(n = 100) and large-sample (n > 100) populations (SMD = -1.008, 95% CI = -1.672 to -0.344, p = 0.003; SMD = -0.863, 95% CI = -1.444 to -0.293, p = 0.003). Meta-analysis revealed a significant association between SLE and vitamin D deficiency (RR = 2.321, 95% CI = 1.361-3.960, p = 0.002). Stratification by ethnicity showed a significant association between SLE and vitamin D deficiency in European and Arab populations (RR = 2.182, 95% CI = 1.024-4.648, p = 0.043; RR = 4.550, 95% CI = 3.471-5.965, p < 1.0 x 10(-8)). Our meta-analysis demonstrates that compared with controls, patients with SLE show significantly low serum levels of vitamin D, and that a deficiency of vitamin D is associated with SLE. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | C M B ASSOC | - |
dc.subject | 25-HYDROXYVITAMIN D | - |
dc.subject | AUTOIMMUNE-DISEASE | - |
dc.subject | EGYPTIAN PATIENTS | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | WOMEN | - |
dc.title | Association between Vitamin D level and/or deficiency, and systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.14715/cmb/2018.64.1.2 | - |
dc.identifier.scopusid | 2-s2.0-85041711758 | - |
dc.identifier.wosid | 000425228400002 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR BIOLOGY, v.64, no.1, pp.7 - 13 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.title | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 7 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | 25-HYDROXYVITAMIN D | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASE | - |
dc.subject.keywordPlus | EGYPTIAN PATIENTS | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | Deficiency | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
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