The role of neuroinflammation and neurovascular dysfunction in major depressive disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Sang Won | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-02T21:24:37Z | - |
dc.date.available | 2021-09-02T21:24:37Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1178-7031 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81026 | - |
dc.description.abstract | Although depression has generally been explained with monoamine theory, it is far more multifactorial, and therapies that address the disease's pathway have not been developed. In this context, an understanding of neuroinflammation and neurovascular dysfunction would enable a more comprehensive approach to depression. Inflammation is in a sense a type of allostatic load involving the immune, endocrine, and nervous systems. Neuroinflammation is involved in the pathophysiology of depression by increasing proinflammatory cytokines, activating the hypothalamus-pituitary-adrenal axis, increasing glucocorticoid resistance, and affecting serotonin synthesis and metabolism, neuronal apoptosis and neurogenesis, and neuroplasticity. In future, identifying the subtypes of depression with increased vulnerability to inflammation and testing the effects of inflammatory modulating agents in these patient groups through clinical trials will lead to more concrete conclusions on the matter. The vascular depression hypothesis is supported by evidence for the association between vascular disease and late-onset depression and between ischemic brain lesions and distinctive depressive symptoms. Vascular depression may be the entity most suitable for studies of the mechanisms of depression. Pharmacotherapies used in the prevention and treatment of cerebrovascular disease may help prevent vascular depression. In future, developments in structural and functional imaging, electrophysiology, chronobiology, and genetics will reveal the association between depression and brain lesions. This article aims to give a general review of the existing issues examined in the literature pertaining to depression-related neuroinflammatory and vascular functions, related pathophysiology, applicability to depression treatment, and directions for future research. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.subject | LATE-LIFE DEPRESSION | - |
dc.subject | WHITE-MATTER LESIONS | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject | GLUCOCORTICOID-RECEPTOR FUNCTION | - |
dc.subject | DORSOLATERAL PREFRONTAL CORTEX | - |
dc.subject | ADULT HIPPOCAMPAL NEUROGENESIS | - |
dc.subject | TREATMENT-RESISTANT DEPRESSION | - |
dc.subject | PRO-INFLAMMATORY CYTOKINES | - |
dc.subject | RANDOMIZED CLINICAL-TRIAL | - |
dc.title | The role of neuroinflammation and neurovascular dysfunction in major depressive disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.2147/JIR.S141033 | - |
dc.identifier.scopusid | 2-s2.0-85047113433 | - |
dc.identifier.wosid | 000431667900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFLAMMATION RESEARCH, v.11, pp.179 - 192 | - |
dc.relation.isPartOf | JOURNAL OF INFLAMMATION RESEARCH | - |
dc.citation.title | JOURNAL OF INFLAMMATION RESEARCH | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 192 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | LATE-LIFE DEPRESSION | - |
dc.subject.keywordPlus | WHITE-MATTER LESIONS | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | GLUCOCORTICOID-RECEPTOR FUNCTION | - |
dc.subject.keywordPlus | DORSOLATERAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | ADULT HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | TREATMENT-RESISTANT DEPRESSION | - |
dc.subject.keywordPlus | PRO-INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | RANDOMIZED CLINICAL-TRIAL | - |
dc.subject.keywordAuthor | depressive disorder | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.subject.keywordAuthor | psychoneuroimmunology | - |
dc.subject.keywordAuthor | vascular depression | - |
dc.subject.keywordAuthor | vascular disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.