Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study
DC Field | Value | Language |
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dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Jang, Byoung Kuk | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Hwang, Jae Seok | - |
dc.contributor.author | Han, Kwang-Hyub | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Lee, Kwan Sik | - |
dc.contributor.author | Kim, Seung Up | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Lee, Jung Il | - |
dc.date.accessioned | 2021-09-02T21:49:21Z | - |
dc.date.available | 2021-09-02T21:49:21Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-12-22 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81138 | - |
dc.description.abstract | Recently, modified REACH-B (mREACH-B) risk prediction model for hepatocellular carcinoma (HCC) development was proposed. We validated the accuracy of the mREACH-B model and compared its accuracy with those of other prediction models. Between 2006 and 2012, 1,241 patients with chronic hepatitis B (CHB) were recruited. All patients underwent transient elastography at enrollment. The median age of the study population (840 males, 401 females) was 49 years. The median PAGE-B, LSM-HCC, and mREACH-B values were 10, 10, and 8, respectively. Among patients without cirrhosis (n = 940, 75.7%), the median REACH-B value was 9. During the follow-up period (median 77.4 months), 66 (5.3%) and 83 (6.7%) patients developed HCC and liver-related events (LRE), respectively. Higher liver stiffness (LS) independently predicted HCC (hazard ratio [HR] = 1.047) and LRE development (HR = 1.047) (all P < 0.05). The mREACH-B significantly predicted HCC (AUC = 0.824 at 3-year and 0.750 at 5-year) and LRE development (AUC = 0.782 at 3-year and 0.739 at 5-year) (all P < 0.001) and it performed similarly or significantly better than the PAGE-B and LSM-HCC (AUC = 0.715-0.809 at 3-year and 0.719-0.742 at 5-year for HCC; AUC = 0.704-0.777 at 3-year and 0.721-0.735 at 5-year for LRE). Among patients without cirrhosis, mREACH-B predicted HCC (AUC = 0.803 vs. 0.654-0.816 at 3-year and 0.684 vs. 0.639-0.738 at 5-year) and LRE development (AUC = 0.734 vs. 0.619-0.789 at 3-year and 0.674 vs. 0.626-0.729 at 5-year) similarly to PAGE-B, REACH-B, and LSM-HCC. mREACH-B appropriately predicted HCC and LRE development in patients with CHB and showed similar or superior accuracy to those of PAGE-B, REACH-B, and LSM-HCC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.subject | CHRONIC HEPATITIS-B | - |
dc.subject | LIVER STIFFNESS MEASUREMENT | - |
dc.subject | CHRONIC VIRAL-HEPATITIS | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | TRANSIENT ELASTOGRAPHY | - |
dc.subject | ANTIVIRAL THERAPY | - |
dc.subject | CIRRHOSIS | - |
dc.subject | FIBROSIS | - |
dc.subject | ACCURACY | - |
dc.subject | SCORE | - |
dc.title | Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Yeon Seok | - |
dc.contributor.affiliatedAuthor | Um, Soon Ho | - |
dc.identifier.doi | 10.18632/oncotarget.22375 | - |
dc.identifier.scopusid | 2-s2.0-85038851176 | - |
dc.identifier.wosid | 000419569800087 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.68, pp.113213 - 113224 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.citation.number | 68 | - |
dc.citation.startPage | 113213 | - |
dc.citation.endPage | 113224 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS-B | - |
dc.subject.keywordPlus | LIVER STIFFNESS MEASUREMENT | - |
dc.subject.keywordPlus | CHRONIC VIRAL-HEPATITIS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | TRANSIENT ELASTOGRAPHY | - |
dc.subject.keywordPlus | ANTIVIRAL THERAPY | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | SCORE | - |
dc.subject.keywordAuthor | hepatitis B | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | transient elastography | - |
dc.subject.keywordAuthor | risk prediction | - |
dc.subject.keywordAuthor | liver stiffness | - |
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