Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Comparison of biannual ultrasonography and annual non-contrast liver magnetic resonance imaging as surveillance tools for hepatocellular carcinoma in patients with liver cirrhosis (MAGNUS-HCC): a study protocol

Authors
Kim, Hyun A.Kim, Kyung AhChoi, Joon-IlLee, Jeong MinLee, Chang HeeKang, Tae WookKu, Young-MiLee, Su LimPark, Yang ShinYoon, Jeong HeeKim, Seong HyunChoi, Moon Hyung
Issue Date
21-12월-2017
Publisher
BIOMED CENTRAL LTD
Keywords
Hepatocellular carcinoma; Liver cirrhosis; Ultrasonography; Magnetic resonance imaging; Surveillance
Citation
BMC CANCER, v.17
Indexed
SCIE
SCOPUS
Journal Title
BMC CANCER
Volume
17
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81141
DOI
10.1186/s12885-017-3819-y
ISSN
1471-2407
Abstract
Background: Ultrasonography (US) is recommended as a standard surveillance tool for patients with a high risk of developing hepatocellular carcinoma (HCC). However, the low sensitivity of US for small HCC can lead to surveillance failure, resulting in advanced stage tumor presentations. For the early detection of HCC in high-risk patients and to improve survival and prognosis, a new efficient imaging tool with a high sensitivity for HCC detection is needed. The purpose of this study is to evaluate and compare the feasibility and efficacy of non-contrast magnetic resonance imaging (MRI) with US as a surveillance tool for HCC in patients with liver cirrhosis. Methods: MAGNUS-HCC is a prospective, multicenter clinical trial with a crossover design for a single arm of patients. This study was approved by six Institutional Review Boards, and informed consent was obtained from all participants. All patients will undergo liver US every 6 months and non-contrast liver MRI every 12 months during a follow-up period of 3 years. If a focal liver lesion suspected of harboring HCC is detected, dynamic liver computed tomography (CT) will be performed to confirm the diagnosis. After the last surveillance round, patients without suspicion of HCC or who are not diagnosed with HCC will be evaluated with a dynamic liver CT to exclude false-negative findings. The primary endpoint is to compare the rate of detection of HCC by US examinations performed at 6-month intervals with that of yearly non-contrast liver MRI studies during a 3-year follow-up. The secondary endpoint is the survival of the patients who developed HCC within the 3-year follow-up period. Discussion: MAGNUS-HCC is the first study to compare the feasibility of non-contrast MRI with US as a surveillance tool for the detection of HCC in high-risk patients. We anticipate that the evidence presented in this study will establish the efficacy of non-contrast MRI as a surveillance tool for HCC in high-risk patients.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Chang Hee photo

Lee, Chang Hee
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE