Near-Infrared Plasmonic Assemblies of Gold Nanoparticles with Multimodal Function for Targeted Cancer Theragnosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Seong-Eun | - |
dc.contributor.author | Lee, Bo-Ram | - |
dc.contributor.author | Lee, Hohyeon | - |
dc.contributor.author | Jo, Sung Duk | - |
dc.contributor.author | Kim, Hyuncheol | - |
dc.contributor.author | Won, You-Yeon | - |
dc.contributor.author | Lee, Jeewon | - |
dc.date.accessioned | 2021-09-02T21:56:42Z | - |
dc.date.available | 2021-09-02T21:56:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-12-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81191 | - |
dc.description.abstract | Here we report a novel assembly structure of near-infrared plasmonic gold nanoparticles (AuNPs), possessing both photoacoustic (PA) and photothermal (PT) properties. The template for the plasmonic AuNP assembly is a bioconjugate between short double-strand DNA (sh-dsDNA) and human methyl binding domain protein 1 (MBD1). MBD1 binds to methylated cytosine-guanine dinucleotides (mCGs) within the sequence of sh-dsDNA. Hexahistidine peptides on the engineered MBD1 function as a nucleation site for AuNP synthesis, allowing the construction of hybrid conjugates, sh-dsDNA-MBD1-AuNPs (named DMAs). By varying the length of sh-dsDNA backbone and the spacer between two adjacent mCGs, we synthesized three different DMAs (DMA_5mCG, DMA_9mCG, and DMA_21mCG), among which DMA_21mCG exhibited a comparable photothermal and surprisingly a higher photoacoustic signals, compared to a plasmonic gold nanorod. Further, epidermal growth factor receptor I (EGFR)-binding peptides are genetically attached to the MBD1 of DMA_21mCG, enabling its efficient endocytosis into EGFR-overexpressing cancer cells. Notably, the denaturation of MBD1 disassembled the DMA and accordingly released the individual small AuNPs (<5 nm) that can be easily cleared from the body through renal excretion without causing accumulation/toxicity problems. This DMA-based novel approach offers a promising platform for targeted cancer theragnosis based on simultaneous PA imaging and PT therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PHOTOTHERMAL THERAPY | - |
dc.subject | NANORODS | - |
dc.subject | TOXICITY | - |
dc.subject | NANOCRYSTALS | - |
dc.subject | CLEARANCE | - |
dc.subject | PEPTIDE | - |
dc.subject | AGENTS | - |
dc.title | Near-Infrared Plasmonic Assemblies of Gold Nanoparticles with Multimodal Function for Targeted Cancer Theragnosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jeewon | - |
dc.identifier.doi | 10.1038/s41598-017-17714-2 | - |
dc.identifier.scopusid | 2-s2.0-85054095227 | - |
dc.identifier.wosid | 000417570500046 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | NANORODS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | AGENTS | - |
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