Innovative micro-textured hydroxyapatite and poly(L-lactic)-acid polymer composite film as a flexible, corrosion resistant, biocompatible, and bioactive coating for Mg implants
- Authors
- Kim, Sae-Mi; Kang, Min-Ho; Kim, Hyoun-Ee; Lim, Ho-Kyung; Byun, Soo-Hwan; Lee, Jong-Ho; Lee, Sung-Mi
- Issue Date
- 1-12월-2017
- Publisher
- ELSEVIER
- Keywords
- Magnesium (Mg); Hydroxyapatite (HA); Micro-textured coating; Poly(-lactic)-acid (PLLA); Biodegradability; Biocompatibility
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.81, pp.97 - 103
- Indexed
- SCIE
SCOPUS
- Journal Title
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
- Volume
- 81
- Start Page
- 97
- End Page
- 103
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81224
- DOI
- 10.1016/j.msec.2017.07.026
- ISSN
- 0928-4931
- Abstract
- The utility of a novel ceramic/polymer-composite coating with a micro-textured microstructure that would significantly enhance the functions of biodegradable Mg implants is demonstrated here. To accomplish this, bioactive hydroxyapatite (HA) micro-dots can be created by immersing a Mg implant with a micro-patterned photoresist surface in an aqueous solution containing calcium and phosphate ions. The HA micro-dots can then be surrounded by a flexible poly(t-lactic)-acid (PLLA) polymer using spin coating to form a HA/PLLA micro-textured coating layer. The HA/PLEA micro-textured coating layer showed an excellent corrosion resistance when it was immersed in a simulated body fluid (SBF) solution and good biocompatibility, which was assessed by in vitro cell tests. In addition, the HA/PLEA micro-textured coating layer had high deformation ability, where no apparent changes in the coating layer were observed even after a 5% elongation, which would be unobtainable using HA and PLEA coating layers; furthermore, this allowed the mechanically-strained Mg implant with the HA/PLIA micro-textured coating layer to preserve its excellent corrosion resistance and biocompatibility in vitro. (C) 2017 Elsevier B.V. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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