Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients
- Authors
- Oh, So Yeon; Shin, Sang Won; Koh, Su-Jin; Bae, Sang Byung; Chang, Hyun; Kim, Jung Han; Kim, Hyo Jung; Hong, Young Seon; Park, Keon Uk; Park, Jeanno; Lee, Kyung Hee; Lee, Na Ri; Lee, Jung Lim; Jang, Joung Soon; Hong, Dae Sik; Lee, Seung-Sei; Baek, Sun Kyung; Choi, Dae Ro; Chung, Jooseop; Oh, Sang Cheul; Han, Hye Sook; Yun, Hwan Jung; Sym, Sun Jin; Yoon, So Young; Choi, In Sil; Shim, Byoung Yong; Kang, Seok Yun; Kim, Sung Rok; Kim, Hyun Joo
- Issue Date
- 12월-2017
- Publisher
- SPRINGER
- Keywords
- Neuropathic pain; Quality of life; Neoplasm; Pain management
- Citation
- SUPPORTIVE CARE IN CANCER, v.25, no.12, pp.3759 - 3767
- Indexed
- SCIE
SCOPUS
- Journal Title
- SUPPORTIVE CARE IN CANCER
- Volume
- 25
- Number
- 12
- Start Page
- 3759
- End Page
- 3767
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81252
- DOI
- 10.1007/s00520-017-3806-5
- ISSN
- 0941-4355
- Abstract
- Neuropathic cancer pain (NCP) is a common and potentially debilitating symptom in cancer patients. We investigated the prevalence of NCP, as well as its management and association with QOL. Cancer patients with pain ae<yen>1 on the visual analogue scale (VAS) were surveyed with the Douleur Neuropathique (DN4) questionnaire, the Brief Pain Inventory-Short Form (BPI-SF), and the EuroQOL five dimensions (EQ-5D) questionnaire. The associations between NCP and pain severity or NCP and QOL, while controlling for variables relevant to QOL, were then analyzed. A total of 2003 patients were enrolled in this survey; the prevalence of NCP was 36.0% (n = 722, 95% CI, 32.5-39.5). We found that NCP in cancer patients was closely correlated to a higher pain severity (BPI-SF; 4.96 +/- 1.94 versus 4.24 +/- 2.02, p < 0.001), and in patients with NCP, pain more severely interfered with daily living, as compared to those without NCP (BPI-SF; 4.86 +/- 2.71 versus 4.41 +/- 2.87, p < 0.001). Patients with NCP also had worse QOL than those without NCP, as measured by EQ-5D index score (0.47 +/- 0.30 vs. 0.51 +/- 0.30, p = 0.005), and this was confirmed using multivariate analysis (p < 0.001), even after controlling for other variables such as age, sex, disease stage, cancer duration, radiotherapy, chemotherapy, and comorbidities. Importantly, adjuvant analgesics were used in less than half of patients with NCP (n = 358, 46.4%). We found that NCP in cancer patients was significantly associated with a worsened QOL, and current management is inadequate. Therefore, future research aimed at developing improved strategies for management of NCP is required.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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