Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

4,4 '-Dichlorodiphenyltrichloroethane (DDT) and 4,4 '-dichlorodiphenyldichloroethylene (DDE) inhibit myogenesis in C2C12 myoblasts

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Jonggun-
dc.contributor.authorPark, Min Young-
dc.contributor.authorKim, Yoo-
dc.contributor.authorYoon, Kyong Sup-
dc.contributor.authorClark, John Marshall-
dc.contributor.authorPark, Yeonhwa-
dc.contributor.authorWhang, Kwang-Youn-
dc.date.accessioned2021-09-02T22:16:21Z-
dc.date.available2021-09-02T22:16:21Z-
dc.date.created2021-06-16-
dc.date.issued2017-12-
dc.identifier.issn0022-5142-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/81300-
dc.description.abstractBACKGROUNDMost countries have banned the use of 4,4-dichlorodiphenyltrichloroethane (DDT). However, owing to its extremely high lipophilic characteristics, DDT and its metabolite 4,4-dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and in many types of food. The positive correlation between exposure to insecticides, including DDT and DDE, and weight gain, resulting in impaired energy metabolism in offspring following perinatal DDT and DDE exposure, was previously reported. Therefore the influence of DDT and DDE on myogenesis using C2C12 myoblasts was investigated in this study. RESULTSDDT and DDE decreased myotube formation dose- and time-dependently. Among myogenic regulatory factors, DDT and DDE mainly decreased MyoD1 and Myf5 expression. DDT and DDE treatment also altered Myostatin expression, phosphorylation of protein kinase B, p70 ribosomal protein S6 kinase, forkhead box O protein 3 and mammalian target of rapamycin, resulting in attenuation of myotube formation. CONCLUSIONThese results may have significant implications for understanding the effects of developmental exposure of DDT and DDE on myogenesis and development of obesity and type 2 diabetes later in life. (c) 2017 Society of Chemical Industry-
dc.languageEnglish-
dc.language.isoen-
dc.publisherWILEY-
dc.subjectSKELETAL-MUSCLE MASS-
dc.subjectTERMINAL DIFFERENTIATION-
dc.subjectMAMMALIAN TARGET-
dc.subjectGENE-EXPRESSION-
dc.subjectINSULIN-
dc.subject3T3-L1-
dc.subjectGROWTH-
dc.subjectMYOD-
dc.subjectPHOSPHORYLATION-
dc.subjectADIPOGENESIS-
dc.title4,4 '-Dichlorodiphenyltrichloroethane (DDT) and 4,4 '-dichlorodiphenyldichloroethylene (DDE) inhibit myogenesis in C2C12 myoblasts-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Min Young-
dc.contributor.affiliatedAuthorWhang, Kwang-Youn-
dc.identifier.doi10.1002/jsfa.8399-
dc.identifier.scopusid2-s2.0-85020215042-
dc.identifier.wosid000414635500015-
dc.identifier.bibliographicCitationJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, v.97, no.15, pp.5176 - 5185-
dc.relation.isPartOfJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE-
dc.citation.titleJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE-
dc.citation.volume97-
dc.citation.number15-
dc.citation.startPage5176-
dc.citation.endPage5185-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaAgriculture-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalWebOfScienceCategoryAgriculture, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Applied-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.subject.keywordPlusSKELETAL-MUSCLE MASS-
dc.subject.keywordPlusTERMINAL DIFFERENTIATION-
dc.subject.keywordPlusMAMMALIAN TARGET-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusINSULIN-
dc.subject.keywordPlus3T3-L1-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusMYOD-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusADIPOGENESIS-
dc.subject.keywordAuthorDDT-
dc.subject.keywordAuthorDDE-
dc.subject.keywordAuthormyogenesis-
dc.subject.keywordAuthorMyoD1-
dc.subject.keywordAuthorAKT-
dc.subject.keywordAuthormTOR-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Life Sciences and Biotechnology > Division of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE