Heterogeneous Nuclear Ribonucleoprotein A2B1 Exerts a Regulatory Role in Lipopolysaccharide-stimulated 38B9 B Cell Activation
DC Field | Value | Language |
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dc.contributor.author | Park, Jisang | - |
dc.contributor.author | Choe, Chung-Hyeon | - |
dc.contributor.author | Kim, Ju | - |
dc.contributor.author | Yang, Jing Shian | - |
dc.contributor.author | Kim, Jin Hyun | - |
dc.contributor.author | Jang, Hyonseok | - |
dc.contributor.author | Jang, Yong-Suk | - |
dc.date.accessioned | 2021-09-02T22:22:05Z | - |
dc.date.available | 2021-09-02T22:22:05Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81347 | - |
dc.description.abstract | Major histocompatibility complex (MHC) class II molecules, which are recognized for their primary function of presenting an antigen to the T cell receptor, are involved in various signaling pathways in B cell activation. We identified heterogeneous nuclear ribonucleoprotein (hnRNP) A2B1 as an MHC class II molecule-associated protein involved in MHC class II-mediated signal transduction in lipopolysaccharide (LPS)-stimulated 38B9 B cells. Although the function of hnRNP A2B1 in the nucleus is primarily known, the level of hnRNP A2B1 in the cytoplasm was increased in LPS-stimulated 38B9 cells, while it was not detected in the cytoplasm of non-treated 38B9 cells. The silencing of hnRNP A2B1 expression using siRNA disturbed B cell maturation by regulation of mitogen-activated protein kinase signaling, NF-kappa B activation, and protein kinase B activation. These results suggest that hnRNP A2B1 is associated with MHC class II molecules and is involved in B cell activation signaling pathways in LPS-stimulated 38B9 cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.subject | MHC CLASS-II | - |
dc.subject | PROLIFERATION | - |
dc.subject | REARRANGEMENT | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | INDUCTION | - |
dc.subject | PATHWAY | - |
dc.subject | KINASE | - |
dc.subject | A2/B1 | - |
dc.subject | GENE | - |
dc.subject | AKT | - |
dc.title | Heterogeneous Nuclear Ribonucleoprotein A2B1 Exerts a Regulatory Role in Lipopolysaccharide-stimulated 38B9 B Cell Activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Hyonseok | - |
dc.identifier.doi | 10.4110/in.2017.17.6.437 | - |
dc.identifier.scopusid | 2-s2.0-85039898193 | - |
dc.identifier.wosid | 000424419700007 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, v.17, no.6, pp.437 - 450 | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.citation.title | IMMUNE NETWORK | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 437 | - |
dc.citation.endPage | 450 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002299879 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | MHC CLASS-II | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | REARRANGEMENT | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | A2/B1 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordAuthor | B cell | - |
dc.subject.keywordAuthor | Heterogeneous-nuclear ribonucleoproteins | - |
dc.subject.keywordAuthor | MHC class II molecule | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Signal transduction | - |
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