CoMIC, the hidden dynamics of mitochondrial inner compartments
- Authors
- Cho, Bongki; Sun, Woong
- Issue Date
- 12월-2017
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Calcium; Constriction; Division; Drp1; Mitochondria
- Citation
- BMB REPORTS, v.50, no.12, pp.597 - 598
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 50
- Number
- 12
- Start Page
- 597
- End Page
- 598
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/81482
- DOI
- 10.5483/BMBRep.2017.50.12.154
- ISSN
- 1976-6696
- Abstract
- Mitochondria have evolutionarily, functionally and structurally distinct outer-(OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.