Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hyung | - |
dc.contributor.author | Choi, Dahee | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Lee, Jeong Hyeon | - |
dc.contributor.author | Koo, Seung-Hoi | - |
dc.date.accessioned | 2021-09-02T22:54:33Z | - |
dc.date.available | 2021-09-02T22:54:33Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-11-28 | - |
dc.identifier.issn | 1471-230X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81499 | - |
dc.description.abstract | Background: Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induced ALI. Non-alcoholic fatty liver disease (NAFLD), the major cause of chronic liver disease, is considered an important predictor of APAP-induced ALI, although the exact mechanism controversial. In this study, we aimed to elucidate the effects of NAFLD on APAP-induced ALI. Methods: Two groups of mice, normal chow (NC) diet-fed and fast food (FF) diet-fed mice for 14 weeks, were further divided into two subgroups: intraperitoneally injected with either saline (NC-S and FF-S groups) or APAP (NC-A and FF-A groups). Biochemical tests, histological analysis, quantitative PCR, and western blotting were conducted. Results: Alanine aminotransferase (ALT) level (199.0 +/- 39.0 vs. 63.8 +/- 7.4 IU/L, p < 0.05) and NAFLD activity score (0 vs. 4.5 +/- 0.22) were significantly higher in mice in FF-S group than those in NC-S group. ALI features such as ALT level (8447.8 +/- 1185.3 vs. 836.6 +/- 185.1 IU/L, p < 0.001) and centrizonal necrosis were prominent and mRNA levels of Trib3 (RR, 1.81) was high in mice in the NC-A group. Levels of CYP2E1 and anti-inflammatory molecules such as PPAR-gamma, p62, and NRF2 were high in mice in the FF-A group. Conclusions: Our results showed that while the FF diet clearly induced non-alcoholic steatohepatitis and metabolic syndrome, NAFLD also attenuates APAP-induced ALI by inducing anti-inflammatory molecules such as PPAR-gamma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | INDUCED HEPATOTOXICITY | - |
dc.subject | UNITED-STATES | - |
dc.subject | INJURY | - |
dc.subject | FAILURE | - |
dc.subject | NRF2 | - |
dc.subject | OVERDOSE | - |
dc.subject | IMPACT | - |
dc.subject | NASH | - |
dc.subject | RATS | - |
dc.title | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Hyung | - |
dc.contributor.affiliatedAuthor | Koo, Seung-Hoi | - |
dc.identifier.doi | 10.1186/s12876-017-0680-z | - |
dc.identifier.scopusid | 2-s2.0-85035115764 | - |
dc.identifier.wosid | 000416213700001 | - |
dc.identifier.bibliographicCitation | BMC GASTROENTEROLOGY, v.17 | - |
dc.relation.isPartOf | BMC GASTROENTEROLOGY | - |
dc.citation.title | BMC GASTROENTEROLOGY | - |
dc.citation.volume | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | OVERDOSE | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | NASH | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Acetaminophen | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Drug-induced liver injury | - |
dc.subject.keywordAuthor | Peroxisome proliferator-activated receptor gamma | - |
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