Restoration of miR-29b exerts anti-cancer effects on glioblastoma
DC Field | Value | Language |
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dc.contributor.author | Shin, Jaekyung | - |
dc.contributor.author | Shim, Hyun Geun | - |
dc.contributor.author | Hwang, Taeyoung | - |
dc.contributor.author | Kim, Hyungsin | - |
dc.contributor.author | Kang, Shin-Hyuk | - |
dc.contributor.author | Dho, Yun-Sik | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.date.accessioned | 2021-09-02T23:01:26Z | - |
dc.date.available | 2021-09-02T23:01:26Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-11-17 | - |
dc.identifier.issn | 1475-2867 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81528 | - |
dc.description.abstract | Background: Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 subfamilies are known to be exclusively expressed in the developing brain, and they are aberrantly down-regulated in GBM. This study aims to elucidate the role of miR-29b in GBM development and the feasibility of therapeutic targeting using conjugated nanoparticles. Methods: After confirmation of miR-29b expression levels in GBM tissues by analysis of open source data, the anticancer effect of miR-29b was tested by the introduction of syn-hsa-miR-29b-3p in the A172 GBM cell line. In vitro studies of cell viability and apoptosis and ex vivo study using GBM tissue slice cultures from 3 patients and nanoparticle delivery of miR-29b were performed. Results: We discovered an increase in apoptotic cell populations with the introduction of miR-29b in the GBM cell line. An established human-derived GBM tissue slice culture system confirmed the anticancer effect of miR29b-conjugated nanoparticles. Using PCR array, we found that exogenous miR-29b inhibits the expression of COL1A2, COL3A1, COL4A1, ELN, ITGA11, MMP24, and SPARC, which mediates an anticancer effect. Conclusions: miR-29b may serve as a putative therapeutic molecule when its expression is restored using a nanoparticle delivery system in GBM. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | MICRORNAS | - |
dc.subject | MIGRATION | - |
dc.subject | SPARC | - |
dc.title | Restoration of miR-29b exerts anti-cancer effects on glioblastoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Shin-Hyuk | - |
dc.identifier.doi | 10.1186/s12935-017-0476-9 | - |
dc.identifier.scopusid | 2-s2.0-85034042960 | - |
dc.identifier.wosid | 000415591000001 | - |
dc.identifier.bibliographicCitation | CANCER CELL INTERNATIONAL, v.17 | - |
dc.relation.isPartOf | CANCER CELL INTERNATIONAL | - |
dc.citation.title | CANCER CELL INTERNATIONAL | - |
dc.citation.volume | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | SPARC | - |
dc.subject.keywordAuthor | Glioblastoma | - |
dc.subject.keywordAuthor | miR-29b | - |
dc.subject.keywordAuthor | Anti-cancer effect | - |
dc.subject.keywordAuthor | Nanoparticle | - |
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