Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Quantification of circulating cell-free DNA to predict patient survival in non-small-cell lung cancer

Authors
Hyun, Myung HanSung, Jae SookKang, Eun JooChoi, Yoon JiPark, Kyong HwaShin, Sang WonLee, Sung YongKim, Yeul Hong
Issue Date
7-11월-2017
Publisher
IMPACT JOURNALS LLC
Keywords
cell-free DNA concentration; prognostic value; non-small-cell lung cancer
Citation
ONCOTARGET, v.8, no.55, pp.94417 - 94430
Indexed
SCIE
SCOPUS
Journal Title
ONCOTARGET
Volume
8
Number
55
Start Page
94417
End Page
94430
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81573
DOI
10.18632/oncotarget.21769
ISSN
1949-2553
Abstract
We used computed tomography (CT) to explore the prognostic value of cell-free (cf) DNA quantification and its predictive efficacy over time after chemotherapy in non-small-cell lung cancer (NSCLC) patients. In total, 177 NSCLC patients were enrolled in a prospective biomarker trial. Consecutive paired blood collection was performed to determine cfDNA concentrations at baseline CT and throughout serial follow-ups. The best cfDNA cut-off value to predict progression-free and overall survival was determined using X-tile analysis. Among 112 chemo-naive patients with stage IV adenocarcinoma, 43 were available for follow-up analysis. Cox regression multivariate analysis indicated that a high cfDNA concentration was an independent negative prognostic factor for progression-free survival (hazard ratio: 2.60; 95% confidence interval: 1.65-4.10; p = 0.008) and overall survival (hazard ratio: 2.63; 95% confidence interval: 1.66-4.17; p < 0.001). However, cfDNA concentration changes during treatment did not correlate with radiological CT responses at first follow-up or best response. No pattern was noted in the percent change in the cfDNA concentration from baseline or subsequently measured level to progression. The serum cfDNA concentration is thus associated with NSCLC patient prognosis, but does not appear to be a clinically valid marker for tumor responses.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Kyong Hwa photo

Park, Kyong Hwa
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE