Low-dose CT for the diagnosis of appendicitis in adolescents and young adults (LOCAT): a pragmatic, multicentre, randomised controlled non-inferiority trial
DC Field | Value | Language |
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dc.contributor.author | Kim Baek-hui | - |
dc.contributor.author | YEOM, Suk keu | - |
dc.contributor.author | CHOI, Sung Hyuk | - |
dc.date.accessioned | 2021-09-02T23:14:18Z | - |
dc.date.available | 2021-09-02T23:14:18Z | - |
dc.date.created | 2021-06-21 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 24681253 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81619 | - |
dc.description.abstract | Background CT radiation is arguably carcinogenic. Results from single-centre studies, mostly retrospective, have advocated lowering the CT radiation dose for the diagnosis of appendicitis. However, adoption of low-dose CT has been slow. We aimed to assess the effectiveness of low-dose CT compared with standard-dose CT in the diagnosis of appendicitis in adolescents and young adults. Methods We did this pragmatic, multicentre, randomised controlled non-inferiority trial at 20 South Korean teaching hospitals with little experience with low-dose CT. Patients aged 15–44 years with suspected appendicitis were randomly assigned (1:1), via computer-generated random assignments (permuted block sizes of two, four, six, and eight) concealed in sequentially numbered envelopes, to receive low-dose CT (2 mSv) or standard-dose CT (≤8 mSv). Randomisation was stratified by site. Group allocation was concealed from patients, outcome assessors, and adverse event adjudicators; care providers, site pathologists, and data collectors were aware of allocation. The primary endpoint was the negative (unnecessary) appendectomy rate among all appendectomies, with a non-interiority margin of 4·5% for low-dose versus standard-dose CT. Primary analysis was by modified intention to treat, which included all pa | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER LTD | - |
dc.title | Low-dose CT for the diagnosis of appendicitis in adolescents and young adults (LOCAT): a pragmatic, multicentre, randomised controlled non-inferiority trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim Baek-hui | - |
dc.contributor.affiliatedAuthor | YEOM, Suk keu | - |
dc.contributor.affiliatedAuthor | CHOI, Sung Hyuk | - |
dc.identifier.doi | 10.1016/S2468-1253(17)30247-9 | - |
dc.identifier.bibliographicCitation | THE LANCET GASTROENTEROLOGY AND HEPATOLOGY, v.2, no.11, pp.793 - 804 | - |
dc.relation.isPartOf | THE LANCET GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.title | THE LANCET GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 2 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 793 | - |
dc.citation.endPage | 804 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
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