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A Case Report of Primary Pericardial Malignant Mesothelioma Treated with Pemetrexed and Cisplatin

Authors
Kim, Jung SunLim, Sang YupHwang, JinwookKang, Eun JooChoi, Yoon Ji
Issue Date
11월-2017
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Primary Pericardial Mesothelioma; Cardiac Tamponade; Pemetrexed; Cisplatin
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.11, pp.1879 - 1884
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
32
Number
11
Start Page
1879
End Page
1884
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81663
DOI
10.3346/jkms.2017.32.11.1879
ISSN
1011-8934
Abstract
Primary pericardial malignant mesothelioma (PPM) is a very rare malignancy, with an incidence of less than 0.002% and represents less than 5% of all mesotheliomas. The cause of pericardial mesothelioma is uncertain that differ from pleural mesothelioma which is associated with asbestos exposure. This malignancy is terribly aggressive and has very poor prognosis with less than six months of overall survival. We present a case of a 71-year-old woman who was diagnosed with cardiac tamponade caused by PPM and received chemotherapy with pemetrexed and cisplatin for six months. During two years she was alive without disease progression. To better understand the clinical, pathologic features and treatment outcome of this entity, we reviewed 23 cases described in the English literature from 2009, together with our case, provided a total of 24 cases. Based on this review, we suggest that PPM must be considered in patients who have unexplained massive pericardial effusion and recommend chemotherapy with pemetrexed and cisplatin for the better outcome of PPM.
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