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Xk-related protein 8 regulates myoblast differentiation and survival

Authors
Kim, Go-WoonNam, Gi-HoonKim, In-SanPark, Seung-Yoon
Issue Date
11월-2017
Publisher
WILEY
Keywords
apoptosis; differentiation; myoblasts; scramblase; Xk-related protein 8
Citation
FEBS JOURNAL, v.284, no.21, pp.3575 - 3588
Indexed
SCOPUS
Journal Title
FEBS JOURNAL
Volume
284
Number
21
Start Page
3575
End Page
3588
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81695
DOI
10.1111/febs.14261
ISSN
1742-464X
Abstract
Xk-related protein 8 (Xkr8) is a scramblase and responsible for phosphatidylserine (PS) exposure on the cell surface in a caspase-dependent manner. Although PS exposure is found to be important for myotube formation during myoblast differentiation, the role of Xkr8 during myogenesis has not been elucidated. Here we show that Xkr8 contributes to myoblast differentiation. Xkr8 overexpression induced the formation of large myotubes during early differentiation, but this phenotype was not related to caspase-dependent cleavage of Xkr8. Furthermore, forced Xkr8 expression accelerated myoblast differentiation and conferred cell-death resistance after the induction of differentiation. Consistent with these results, Xkr8-knocked-down myoblasts exhibited impaired differentiation and more apoptotic cells during differentiation, implying the involvements of Xkr8 in the survival and proliferation of myoblasts. Taken together, the study shows Xkr8 influences myogenesis by acting as a positive regulator of terminal differentiation and myoblast survival.
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