A BODIPY-based two-photon fluorescent probe validates tyrosinase activity in live cells
DC Field | Value | Language |
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dc.contributor.author | Bobba, Kondapa Naidu | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Shim, Inseob | - |
dc.contributor.author | Velusamy, Nithya | - |
dc.contributor.author | Yang, Zhigang | - |
dc.contributor.author | Qu, Junle | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Bhuniya, Sankarprasad | - |
dc.date.accessioned | 2021-09-03T00:06:44Z | - |
dc.date.available | 2021-09-03T00:06:44Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10-18 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81886 | - |
dc.description.abstract | Herein, we report rational design, synthesis, and application of a two-photon fluorescent probe (Tyro-1) for tracking intracellular tyrosinase activity. The chemoselective detection of tyrosinase is precluded from interference of other competitive omnipresent oxidizing entities in cellular milieu. The probe showed 12.5-fold fluorescence enhancement at lambda(em) = 450 nm in the presence of tyrosinase. The nontoxic probe Tyro-1 provides information about H2O2-mediated upregulation of tyrosinase through cellular imaging. Its two-photon imaging ability makes it a noninvasive tool for validating the expression of tyrosinase in the live cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | MELANOMA-CELLS | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | LIVING CELLS | - |
dc.subject | DESIGN | - |
dc.subject | CANCER | - |
dc.subject | PEROXYNITRITE | - |
dc.subject | SULFIDE | - |
dc.subject | TISSUES | - |
dc.subject | STRESS | - |
dc.title | A BODIPY-based two-photon fluorescent probe validates tyrosinase activity in live cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, Miae | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1039/c7cc05043g | - |
dc.identifier.scopusid | 2-s2.0-85031003246 | - |
dc.identifier.wosid | 000412760500026 | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.53, no.81, pp.11213 - 11216 | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 53 | - |
dc.citation.number | 81 | - |
dc.citation.startPage | 11213 | - |
dc.citation.endPage | 11216 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PEROXYNITRITE | - |
dc.subject.keywordPlus | SULFIDE | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | STRESS | - |
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