ScholarWorks@Korea University

Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Synthesis and biological evaluation of peptide-derived TSLP inhibitors

Full metadata record
DC Field Value Language
dc.contributor.authorPark, Seonghu-
dc.contributor.authorPark, Yeeun-
dc.contributor.authorSon, Sang-Hyun-
dc.contributor.authorLee, Kiho-
dc.contributor.authorJung, Yong Woo-
dc.contributor.authorLee, Ki Yong-
dc.contributor.authorJeon, Young Ho-
dc.contributor.authorByun, Youngjoo-
dc.date.accessioned2021-09-03T00:08:53Z-
dc.date.available2021-09-03T00:08:53Z-
dc.date.created2021-06-19-
dc.date.issued2017-10-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/81898-
dc.description.abstractThymic stromal lymphopoietin (TSLP) is a type II cytokine which is associated with most inflammatory allergic disorders in humans. It is produced mainly by epithelial cells with important role in the development of chronic inflammatory diseases by activating T-helper cell type-2 (T(H)2) pathways. In this study, a total of 16 peptides were prepared by solid phase peptide synthesis based on amino acid sequences of the interface between TSLP and TSLP receptor. Their TSLP inhibition activities were determined by ELISA assay. Among them, three peptides (6-8) exhibited >50% inhibition at concentration of 0.3 mM. They can be used as hit compounds for developing peptide-based TSLP inhibitors. (C) 2017 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectTHYMIC STROMAL LYMPHOPOIETIN-
dc.subjectRECEPTOR-
dc.subjectCLONING-
dc.subjectCOMPLEX-
dc.subjectALLERGY-
dc.subjectINFLAMMATION-
dc.subjectMECHANISMS-
dc.subjectASTHMA-
dc.subjectSTAT5-
dc.titleSynthesis and biological evaluation of peptide-derived TSLP inhibitors-
dc.typeArticle-
dc.contributor.affiliatedAuthorSon, Sang-Hyun-
dc.contributor.affiliatedAuthorJung, Yong Woo-
dc.contributor.affiliatedAuthorLee, Ki Yong-
dc.contributor.affiliatedAuthorJeon, Young Ho-
dc.contributor.affiliatedAuthorByun, Youngjoo-
dc.identifier.doi10.1016/j.bmcl.2017.09.010-
dc.identifier.scopusid2-s2.0-85029547109-
dc.identifier.wosid000412863700022-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.20, pp.4710 - 4713-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume27-
dc.citation.number20-
dc.citation.startPage4710-
dc.citation.endPage4713-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusTHYMIC STROMAL LYMPHOPOIETIN-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusCLONING-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusALLERGY-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusASTHMA-
dc.subject.keywordPlusSTAT5-
dc.subject.keywordAuthorAllergic disease-
dc.subject.keywordAuthorTSLP inhibitors-
dc.subject.keywordAuthorPeptides-
dc.subject.keywordAuthorTSLP receptors-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
Show simple item record

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Ki Yong photo

Lee, Ki Yong
약학대학 (약학과)
Read more

Altmetrics

Total Views & Downloads

STATISTICS
Total View :8,665,357
Today View :24,480

RSS_1.0 RSS_2.0 ATOM_1.0

CONTACT US

(02841) 서울특별시 성북구 안암로 14502-3290-1114

COPYRIGHT © 2021 Korea University. All Rights Reserved.

Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.

BROWSE

English