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Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis

Authors
Kwon, Koo ChulJo, EunjiKwon, Young-WanLee, BoramRyu, Ju HeeLee, Eun JungKim, KwangmeyungLee, Jeewon
Issue Date
11-10월-2017
Publisher
WILEY-V C H VERLAG GMBH
Keywords
cancer targeting; cancer theragnosis; magnetic hyperthermia therapy; magnetic resonance imaging (MRI); superparamagnetic gold nanoparticles
Citation
ADVANCED MATERIALS, v.29, no.38
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED MATERIALS
Volume
29
Number
38
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/81915
DOI
10.1002/adma.201701146
ISSN
0935-9648
Abstract
Cancer theragnosis using a single multimodality agent is the next mainstay of modern cancer diagnosis, treatment, and management, but a clinically feasible agent with in vivo cancer targeting and theragnostic efficacy has not yet been developed. A new type of cancer theragnostic agent is reported, based on gold magnetism that is induced on a cancer-targeting protein particle carrier. Superparamagnetic gold-nanoparticle clusters (named SPAuNCs) are synthesized on a viral capsid particle that is engineered to present peptide ligands targeting a tumor cell receptor (TCR). The potent multimodality of the SPAuNCs is observed, which enables TCR-specific targeting, T-2-weighted magnetic resonance imaging, and magnetic hyperthermia therapy of both subcutaneous and deep-tissue tumors in live mice under an alternating magnetic field. Furthermore, it is analytically elucidated how the magnetism of the SPAuNCs is sufficiently induced between localized and delocalized spins of Au atoms. In particular, the SPAuNCs show excellent biocompatibility without the problem of in vivo accumulation and holds promising potential as a clinically effective agent for cancer theragnosis.
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공과대학 (화공생명공학과)
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