Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation:Multicenter Prospective Randomized Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Hwang, Minki | - |
dc.contributor.author | Song, Jun-Seop | - |
dc.contributor.author | Lim, Byounghyun | - |
dc.contributor.author | Kim, Tae-Hoon | - |
dc.contributor.author | Joung, Boyoung | - |
dc.contributor.author | Kim, Sung-Hwan | - |
dc.contributor.author | Oh, Yong-Seog | - |
dc.contributor.author | Nam, Gi-Byung | - |
dc.contributor.author | On, Young Keun | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.contributor.author | Pak, Hui-Nam | - |
dc.date.accessioned | 2021-09-03T00:11:04Z | - |
dc.date.available | 2021-09-03T00:11:04Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10-11 | - |
dc.identifier.issn | 1664-042X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81916 | - |
dc.description.abstract | Objective : Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible and more effective than an empirically chosen ablation lesion set (Em-ABL) in patients with PeAF. Methods: We prospectively included 108 patients with antiarrhythmic drug-resistant PeAF (77.8% men, age 60.8 +/- 9.9 years), and randomly assigned them to the V-ABL (n = 53) and Em-ABL (n = 55) groups. Five different in-silico ablation lesion sets [1 pulmonary vein isolation (PVI), 3 linear ablations, and 1 electrogram-guided ablation] were compared using heart-CT integrated AF modeling. We evaluated the feasibility, safety, and efficacy of V-ABL compared with that of Em-ABL. Results: The pre-procedural computing time for five different ablation strategies was 166 +/- 11min. In the Em-ABL group, the earliest terminating blinded in-silico lesion set matched with the Em-ABL lesion set in 21.8%. V-ABL was not inferior to Em-ABL in terms of procedure time (p = 0.403), ablation time (p = 0.510), and major complication rate (p = 0.900). During 12.6 +/- 3.8 months of follow-up, the clinical recurrence rate was 14.0% in the V-ABL group and 18.9% in the Em-ABL group (p = 0.538). In Em-ABL group, clinical recurrence rate was significantly lower after PVI+ posterior box+ anterior linear ablation, which showed the most frequent termination during in-silico ablation (log-rank p = 0.027). Conclusions: V-ABL was feasible in clinical practice, not inferior to Em-ABL, and predicts the most effective ablation lesion set in patients who underwent PeAF ablation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | PULMONARY VEIN ISOLATION | - |
dc.subject | CLINICAL RECURRENCE | - |
dc.subject | TRIAL | - |
dc.subject | MULTICENTER | - |
dc.subject | MECHANISMS | - |
dc.subject | MANAGEMENT | - |
dc.subject | SUBSTRATE | - |
dc.subject | INSIGHTS | - |
dc.subject | SITES | - |
dc.subject | AF | - |
dc.title | Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation:Multicenter Prospective Randomized Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.contributor.affiliatedAuthor | Kim, Young-Hoon | - |
dc.identifier.doi | 10.3389/fphys.2017.00792 | - |
dc.identifier.scopusid | 2-s2.0-85031109770 | - |
dc.identifier.wosid | 000412705600001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHYSIOLOGY, v.8 | - |
dc.relation.isPartOf | FRONTIERS IN PHYSIOLOGY | - |
dc.citation.title | FRONTIERS IN PHYSIOLOGY | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | PULMONARY VEIN ISOLATION | - |
dc.subject.keywordPlus | CLINICAL RECURRENCE | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | SITES | - |
dc.subject.keywordPlus | AF | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | catheter ablation | - |
dc.subject.keywordAuthor | virtual a blation | - |
dc.subject.keywordAuthor | in-silico modeling | - |
dc.subject.keywordAuthor | recurrence | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.