Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor
DC Field | Value | Language |
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dc.contributor.author | Park, Yoonhwa | - |
dc.contributor.author | Woo, Sang Hyeok | - |
dc.contributor.author | Seo, Sung-Keum | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.contributor.author | Noh, Woo Chul | - |
dc.contributor.author | Lee, Jin Kyung | - |
dc.contributor.author | Kwon, Byoung-Mog | - |
dc.contributor.author | Min, Kyung Nam | - |
dc.contributor.author | Choe, Tae-Boo | - |
dc.contributor.author | Park, In-Chul | - |
dc.date.accessioned | 2021-09-03T00:17:22Z | - |
dc.date.available | 2021-09-03T00:17:22Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81965 | - |
dc.description.abstract | Ginkgetin is a natural biflavonoid isolated from the leaves of Ginkgo biloba, and is characterized by its anti-inflammatory and anti-viral activities. Although numerous studies state that it has also antitumor activity, the anti-proliferative effect of ginkgetin and the underlying mechanism in breast cancer cells have not yet been investigated. In the present study, ginkgetin inhibited the cell viability of MCF-7 and T-47D cells dose-dependently, and suppressed the expression of the estrogen receptor (ER) at the mRNA and protein levels. Among the targets of the ER, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), cyclin D1 and survivin were also downregulated by ginkgetin treatment. The anti-proliferative effects of ginkgetin were sufficient to suppress the growth by estradiol stimulation. However, ginkgetin did not significantly affect the viability of MDA-MB-231 cells, which are ER-negative cells. Furthermore, the knockdown of the ER and an inhibitor of PFKFB3 significantly sensitized MCF-7 and T-47D cells to ginkgetin. These findings suggest that ginkgetin induces cell death in ER-positive breast cancer cells via the inhibition of ER expression and that it is a promising agent for breast cancer treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | ER-ALPHA | - |
dc.subject | PROGESTERONE-RECEPTOR | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISMS | - |
dc.subject | APOPTOSIS | - |
dc.subject | SURVIVAL | - |
dc.subject | BINDING | - |
dc.title | Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.3892/ol.2017.6742 | - |
dc.identifier.scopusid | 2-s2.0-85028924264 | - |
dc.identifier.wosid | 000413151300166 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, v.14, no.4, pp.5027 - 5033 | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.citation.title | ONCOLOGY LETTERS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 5027 | - |
dc.citation.endPage | 5033 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | ER-ALPHA | - |
dc.subject.keywordPlus | PROGESTERONE-RECEPTOR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | ginkgetin | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | estrogen receptor | - |
dc.subject.keywordAuthor | breast cancer | - |
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