Circulating prolactin level in systemic lupus erythematosus and its correlation with disease activity: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, G. G. | - |
dc.contributor.author | Lee, Y. H. | - |
dc.date.accessioned | 2021-09-03T00:17:49Z | - |
dc.date.available | 2021-09-03T00:17:49Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81968 | - |
dc.description.abstract | Objective This study aimed to evaluate the relationship between circulating prolactin level and systemic lupus erythematosus (SLE), and to establish a correlation between plasma/serum prolactin levels and SLE activity. Methods We performed a meta-analysis comparing the plasma/serum prolactin levels in patients with SLE to controls, and examined correlation coefficients between circulating prolactin level and SLE disease activity. Results Twenty-five studies with a total of 1056 SLE patients and 426 controls were included. Prolactin levels were significantly higher overall in the SLE group than in the control group (standardized mean difference (SMD)=0.987, 95% CI=0.512-1.463, p=4.7x10(-5)). Stratification by ethnicity showed significantly elevated prolactin levels in the SLE group in Asian, Latin American, and mixed populations (SMD=0.813, 95% CI=0.137-1.490, p=0.018; SMD=0.981, 95% CI=0.307-1.655, p=0.004; SMD=1.469, 95% CI=0.443-2.495, p=0.005, respectively), but not in the European population. Subgroup analysis by sample size showed significantly higher prolactin levels in the SLE group by small (n<30) and large sample numbers (n>30). Meta-analysis of correlation coefficients showed a significantly positive correlation between circulating prolactin level and SLE activity (correlation coefficient=0.379, 95% CI=0.026-0.487, p=4.0x10(-9)). Circulating prolactin levels were positively associated with SLE activity in European, Asian, and mixed populations (SMD=0.532, 95% CI=0.443-0.609p<1.0x10(-8); SMD=0.427, 95% CI=0.240-0.583, p=2.4x10(-5); SMD=0.433, 95% CI=0.212-0.591, p=2.7x10(-5), respectively). Conclusions Our meta-analysis demonstrated that circulating prolactin levels are higher in patients with SLE, and that a significantly positive correlation exists between prolactin levels and SLE activity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | SEX-HORMONES | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | CLINICAL ACTIVITY | - |
dc.subject | HYPERPROLACTINEMIA | - |
dc.subject | HETEROGENEITY | - |
dc.subject | ASSOCIATION | - |
dc.subject | GROWTH | - |
dc.subject | PLASMA | - |
dc.subject | BIAS | - |
dc.title | Circulating prolactin level in systemic lupus erythematosus and its correlation with disease activity: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1177/0961203317693094 | - |
dc.identifier.scopusid | 2-s2.0-85029094097 | - |
dc.identifier.wosid | 000410986400003 | - |
dc.identifier.bibliographicCitation | LUPUS, v.26, no.12, pp.1260 - 1268 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 26 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1260 | - |
dc.citation.endPage | 1268 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | SEX-HORMONES | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | CLINICAL ACTIVITY | - |
dc.subject.keywordPlus | HYPERPROLACTINEMIA | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Prolactin | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordAuthor | activity | - |
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