Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study
DC Field | Value | Language |
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dc.contributor.author | Choi, Jae-Ki | - |
dc.contributor.author | Cho, Sung-Yeon | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Moon, Joon-Ho | - |
dc.contributor.author | Kim, Sung -Han | - |
dc.contributor.author | Lee, Je-Hwan | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Cheong, June-Won | - |
dc.contributor.author | Jang, Jun-Ho | - |
dc.contributor.author | Seo, Bo-Jeong | - |
dc.contributor.author | Kim, Young-Joo | - |
dc.contributor.author | Lee, Hye-Jung | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Lee, Jong Wook | - |
dc.contributor.author | Lee, Dong-Gun | - |
dc.date.accessioned | 2021-09-03T00:23:14Z | - |
dc.date.available | 2021-09-03T00:23:14Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82009 | - |
dc.description.abstract | Incidence, epidemiology, and risk factors of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients can vary from different cohorts and countries. Therefore, we performed a nationwide study to establish a proper antifungal prophylaxis strategies based on risk stratifications of IFDs after all-HSCT in Korea (RISK study). This was a multicenter, retrospective, and observational study in Korea. All consecutive adult patients who received allo-HSCT in 2013 were included. The 12-month cumulative incidence of proven/probable IFDs (PP-IFDs) was calculated during the early (days 0 to 40), late (days 41 to 100), and very late (days 101 to 365) phases after allo-HSCT. Cox proportional hazard regression analysis was performed to identify risk factors for PP-IFDs at each phase. A total 521 allo-HSCT cases in 518 patients were analyzed. Overall cumulative incidence of PP-IFDs were 4.09% (95% confidence interval [CI], 2.38 to 5.81), 738% (95% CI, 5.09 to 9.67), and 15.36% (95% CI, 12.04 to 18.68) at the early, late and very phases, respectively. In multiple Cox regression analysis, variables were associated with PP-IFDs in each period were identified. Variables associated with early phase include underlying pulmonary diseases, underlying nonmalignant stable or chronic disease at allo-HSCT, unrelated or family mismatched donor, and prolonged neutropenia. Variables associated with the late phase include high ferritin level at the time point of allo-HSCT, use of secondary immunosuppressive agents due to refractory graft-versus-host disease (GVHD), and cytomegalovirus reactivation. For the very late phase, variables were secondary neutropenia, severe chronic GVHD, and use of TNF-alpha inhibitor for refractory GVHD. This study revealed the high cumulative incidence of IFDs in Korean allo-HSCT recipients, which have distinct risk factors in each phase after allo-HSCT. Our findings indicate that tailored antifungal prophylaxis is necessary for high-risk patients. Clinicians should consider using mold active antifungal prophylaxis in allo-HSCT recipients who have high risks at different treatment period. (C) 2017 American Society for Blood and Marrow Transplantation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | MIDOLLO OSSEO GITMO | - |
dc.subject | ANTIFUNGAL PROPHYLAXIS | - |
dc.subject | MOLD INFECTIONS | - |
dc.subject | ASPERGILLOSIS | - |
dc.subject | EMERGENCE | - |
dc.subject | DIAGNOSIS | - |
dc.title | Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1016/j.bbmt.2017.06.012 | - |
dc.identifier.scopusid | 2-s2.0-85027256026 | - |
dc.identifier.wosid | 000412152600025 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.23, no.10, pp.1773 - 1779 | - |
dc.relation.isPartOf | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.citation.title | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.citation.volume | 23 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1773 | - |
dc.citation.endPage | 1779 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | MIDOLLO OSSEO GITMO | - |
dc.subject.keywordPlus | ANTIFUNGAL PROPHYLAXIS | - |
dc.subject.keywordPlus | MOLD INFECTIONS | - |
dc.subject.keywordPlus | ASPERGILLOSIS | - |
dc.subject.keywordPlus | EMERGENCE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | Hematopoietic stem cell transplantation | - |
dc.subject.keywordAuthor | Mycoses | - |
dc.subject.keywordAuthor | Epidemiology | - |
dc.subject.keywordAuthor | Risk factors | - |
dc.subject.keywordAuthor | Republic of Korea | - |
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