Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis
- Authors
- Lee, Y. H.; Bae, S. -C.
- Issue Date
- 10월-2017
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Systemic lupus erythematosus; Rheumatoid arthritis; Endothelial nitric oxide synthase; Polymorphism; Meta-analysis
- Citation
- ZEITSCHRIFT FUR RHEUMATOLOGIE, v.76, no.8, pp.708 - 715
- Indexed
- SCIE
SCOPUS
- Journal Title
- ZEITSCHRIFT FUR RHEUMATOLOGIE
- Volume
- 76
- Number
- 8
- Start Page
- 708
- End Page
- 715
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82014
- DOI
- 10.1007/s00393-016-0157-4
- ISSN
- 0340-1855
- Abstract
- Objective. The aim of this study was to determine whether endothelial nitric oxide synthase (eNOS) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Methods. A meta-analysis was conducted on associations between the 4b/a, T786C, and G894T polymorphisms of eNOS and SLE or RA using the following methods: (1) allele contrast, (2) recessive model, (3) dominant model, and (4) homozygous contrast. Results. Nineteen studies were included in this meta-analysis, comprising eleven studies on SLE (1561 patients and 1565 controls) and eight on RA (1624 patients and 2118 controls). Meta-analysis showed a significant association between SLE and the 4b/a polymorphism using the recessivemodel and the homozygous contrast (odds ratio [OR] = 1.836, 95% confidence interval [CI] = 1.171-2.878, p = 0.008; OR = 2.055, 95% CI = 1.302-3.243, p = 0.002). Ethnicity-specific meta-analysis showed a significant association between the aa vs. bb of the 4b/a polymorphism and SLE in European populations (OR = 2.096, 95% CI = 1.288-4.0, p = 0.027), but not in Arab populations. Stratification by presence of lupus nephritis (LN) indicated a significant association between the a allele and the aa + ab genotype of the 4b/a polymorphismand LN in SLE patients (OR = 2.125, 95% CI = 1.289-3.054, p = 0.003; OR = 2.655, 95% CI = 1.509-4.671, p = 0.001). Meta-analysis indicated no association between SLE and the T786C and G894T polymorphisms. No association was found between the eNOS 4b/a, T786C, and G894T polymorphisms and RA Conclusions. This meta-analysis of published studies shows that the eNOS 4b/a polymorphism may be associated with the development of SLE, but the 4b/a, T786C, and G894T polymorphismsmay be not associated with RA susceptibility.
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