Wild-type p53 controls the level of fibronectin expression in breast cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | You, Daeun | - |
dc.contributor.author | Jung, Seung Pil | - |
dc.contributor.author | Jeong, Yisun | - |
dc.contributor.author | Bae, Soo Youn | - |
dc.contributor.author | Kim, Sangmin | - |
dc.date.accessioned | 2021-09-03T00:48:41Z | - |
dc.date.available | 2021-09-03T00:48:41Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82060 | - |
dc.description.abstract | Aberrant fibronectin (FN) expression is associated with poor prognosis, cell adhesion, and cell motility in a variety of cancer cells. In this study, we investigated the relationship between p53 and FN expression in breast cancer cells. Basal FN expression was significantly decreased by treatment with the p53 activator III, RITA, in MCF7 breast cancer cells with wild-type p53. In addition, overexpression of wild-type p53 markedly decreased the level of FN expression in p53-mutant breast cancer cells. To examine the mechanism underlying the relationship between p53 and FN expression, we treated MCF7 breast cancer cells with the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate). Our results showed that basal FN expression was increased by TPA treatment in a time-dependent manner. In contrast, the level of p53 expression was decreased by TPA treatment. However, the expression of FN and p53 was not altered by TPA in p53-mutant breast cancer cells. Furthermore, the alterations in FN and p53 expression in response to TPA were prevented by a specific MEK inhibitor, UO126. Finally, we demonstrated that TPA triggers degradation of p53 through the proteasomal pathway in MCF7 cells. TPA-induced FN expression was decreased by the proteasome inhibitor MG132. Under the same condition, p53 protein expression, but not mRNA expression, was reversed by MG132. Taken together, our data demonstrate that the level of FN expression is associated with the status and expression of p53 in breast cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | SMALL-MOLECULE RITA | - |
dc.subject | MUTANT P53 | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | CARCINOMA-CELLS | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | METASTASIS | - |
dc.subject | INHIBITION | - |
dc.subject | APOPTOSIS | - |
dc.subject | ADHESION | - |
dc.title | Wild-type p53 controls the level of fibronectin expression in breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Seung Pil | - |
dc.contributor.affiliatedAuthor | Bae, Soo Youn | - |
dc.identifier.doi | 10.3892/or.2017.5860 | - |
dc.identifier.scopusid | 2-s2.0-85029809232 | - |
dc.identifier.wosid | 000411688200075 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.38, no.4, pp.2551 - 2557 | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 38 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2551 | - |
dc.citation.endPage | 2557 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | SMALL-MOLECULE RITA | - |
dc.subject.keywordPlus | MUTANT P53 | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | CARCINOMA-CELLS | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordAuthor | fibronectin | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | MEK | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | proteasomal degradation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.