Computer-assisted measurement of primary tumor area is prognostic of recurrence-free survival in stage IB melanoma patients
DC Field | Value | Language |
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dc.contributor.author | Rosenbaum, Brooke E. | - |
dc.contributor.author | Schafer, Christine N. | - |
dc.contributor.author | Han, Sung Won | - |
dc.contributor.author | Osman, Iman | - |
dc.contributor.author | Zhong, Hua | - |
dc.contributor.author | Brinster, Nooshin | - |
dc.date.accessioned | 2021-09-03T00:53:28Z | - |
dc.date.available | 2021-09-03T00:53:28Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0893-3952 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82097 | - |
dc.description.abstract | Current staging guidelines are insufficient to predict which patients with thin primary melanoma are at high risk of recurrence. Computer-assisted image analysis may allow for more practical and objective histopathological analysis of primary tumors than traditional light microscopy. We studied a prospective cohort of stage IB melanoma patients treated at NYU Langone Medical Center from 2002 to 2014. Primary tumor width, manual area, digital area, and conformation were evaluated in a patient subset via computer-assisted image analysis. The associations between histologic variables and survival were evaluated using Cox proportional hazards model. Logistic regressions were used to build a classifier with clinicopathological characteristics to predict recurrence status. Of the 655 patients with stage IB melanoma studied, a subset of 149 patient tumors (63 recurred, 86 did not recur) underwent computer-assisted histopathological analysis. Increasing tumor width (hazard ratios (HR): 1.17, P=0.01) and digital area (HR: 1.08, P < 0.01) were significantly associated with worse recurrence-free survival, whereas non-contiguous conformation (HR: 0.57, P=0.05) was significantly associated with better recurrence-free survival. The novel histopathological classifier composed of digital area, conformation, and baseline variables effectively distinguished recurrent cases from non-recurrent cases (AUC: 0.733, 95% confidence interval (CI): 0.647-0.818), compared to the baseline classifier alone (AUC: 0.635, 95% CI: 0.545-0.724). Primary tumor cross-sectional area, width, and conformation measured via computer-assisted analysis may help identify high-risk patients with stage IB melanoma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PRIMARY CUTANEOUS MELANOMA | - |
dc.subject | AMERICAN JOINT COMMITTEE | - |
dc.subject | CROSS-SECTIONAL AREA | - |
dc.subject | MALIGNANT-MELANOMA | - |
dc.subject | MITOTIC RATE | - |
dc.subject | FOLLOW-UP | - |
dc.subject | CANCER | - |
dc.subject | VOLUME | - |
dc.subject | DIAMETER | - |
dc.subject | METASTASES | - |
dc.title | Computer-assisted measurement of primary tumor area is prognostic of recurrence-free survival in stage IB melanoma patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Sung Won | - |
dc.identifier.doi | 10.1038/modpathol.2017.64 | - |
dc.identifier.scopusid | 2-s2.0-85030648080 | - |
dc.identifier.wosid | 000412100400006 | - |
dc.identifier.bibliographicCitation | MODERN PATHOLOGY, v.30, no.10, pp.1402 - 1410 | - |
dc.relation.isPartOf | MODERN PATHOLOGY | - |
dc.citation.title | MODERN PATHOLOGY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1402 | - |
dc.citation.endPage | 1410 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | PRIMARY CUTANEOUS MELANOMA | - |
dc.subject.keywordPlus | AMERICAN JOINT COMMITTEE | - |
dc.subject.keywordPlus | CROSS-SECTIONAL AREA | - |
dc.subject.keywordPlus | MALIGNANT-MELANOMA | - |
dc.subject.keywordPlus | MITOTIC RATE | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | DIAMETER | - |
dc.subject.keywordPlus | METASTASES | - |
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