Generation of induced pluripotent stem cell (iPSC) line from Charcot- Marie- Tooth disease patient with MPZ mutation (CMT1B)
DC Field | Value | Language |
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dc.contributor.author | Son, Daryeon | - |
dc.contributor.author | Kang, Phil Jun | - |
dc.contributor.author | Yun, Wonjin | - |
dc.contributor.author | You, Seungkwon | - |
dc.date.accessioned | 2021-09-03T00:54:46Z | - |
dc.date.available | 2021-09-03T00:54:46Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82108 | - |
dc.description.abstract | Charcot-Marie-Tooth disease (CMT1B) is an inherited neurological disorder caused by mutation of the myelin protein zero (MPZ) gene. We generated an induced pluripotent stem cell (iPSC) line from an 81-year-old patient with CMT1B by electroporating of lymphoblastoid cell lines with episomal plasmids encoding OCT4, SOX2, KLF4, L-MYC, LIN28, and p53-targeting shRNA. The established iPSCs expressed various pluripotency markers, demonstrated the potential to differentiate into cells of the three germ layers in vitro, had a normal karyotype and retained the MPZ mutation. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Generation of induced pluripotent stem cell (iPSC) line from Charcot- Marie- Tooth disease patient with MPZ mutation (CMT1B) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Phil Jun | - |
dc.contributor.affiliatedAuthor | You, Seungkwon | - |
dc.identifier.doi | 10.1016/j.scr.2017.08.002 | - |
dc.identifier.scopusid | 2-s2.0-85029416726 | - |
dc.identifier.wosid | 000416090100002 | - |
dc.identifier.bibliographicCitation | STEM CELL RESEARCH, v.24, pp.5 - 7 | - |
dc.relation.isPartOf | STEM CELL RESEARCH | - |
dc.citation.title | STEM CELL RESEARCH | - |
dc.citation.volume | 24 | - |
dc.citation.startPage | 5 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
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