Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Wonyong | - |
dc.contributor.author | Song, Jie-Young | - |
dc.contributor.author | Oh, Se Won | - |
dc.contributor.author | Kim, Myung Gyu | - |
dc.contributor.author | Ko, Yoon Sook | - |
dc.contributor.author | Lee, Hee Yong | - |
dc.contributor.author | Jo, Sang Kyung | - |
dc.date.accessioned | 2021-09-03T01:00:34Z | - |
dc.date.available | 2021-09-03T01:00:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82154 | - |
dc.description.abstract | Effective clearance of inflammatory cells is required for resolution of inflammation. Here, we show in vivo evidence that apoptosis and reverse transendothelial migration (rTEM) are important mechanisms in eliminating neutrophils and facilitating recovery following ischemia/reperfusion injury (IRI) of the kidney. The clearance of neutrophils was delayed in the Bax knockout (KO)(BM) -> wild-type (WT) chimera in which bone marrow derived cells are partially resistant to apoptosis, compared to WTBM -> WT mice. These mice also showed delayed functional, histological recovery, increased tissue cytokines, and accelerated fibrosis. The circulating intercellular adhesion molecule-1 (ICAM-1)(+) Gr-1(+) neutrophils displaying rTEM phenotype increased during the recovery phase and blockade of junctional adhesion molecule-C (JAM-C), a negative regulator of rTEM, resulted in an increase in circulating ICAM-1(+) neutrophils, faster resolution of inflammation and recovery. The presence of Tamm-Horsfall protein (THP) in circulating ICAM-1(+) neutrophils could suggest that they are derived from injured kidneys. In conclusion, we suggest that apoptosis and rTEM are critically involved in the clearance mechanisms of neutrophils during the recovery phase of IRI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | CRITICALLY-ILL PATIENTS | - |
dc.subject | ACUTE-RENAL-FAILURE | - |
dc.subject | TRANSENDOTHELIAL MIGRATION | - |
dc.subject | CELL-DEATH | - |
dc.subject | INFLAMMATION | - |
dc.subject | RESOLUTION | - |
dc.subject | BAX | - |
dc.subject | POPULATION | - |
dc.subject | CONTRIBUTE | - |
dc.subject | ZEBRAFISH | - |
dc.title | Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Wonyong | - |
dc.contributor.affiliatedAuthor | Oh, Se Won | - |
dc.contributor.affiliatedAuthor | Kim, Myung Gyu | - |
dc.contributor.affiliatedAuthor | Jo, Sang Kyung | - |
dc.identifier.doi | 10.3346/jkms.2017.32.10.1616 | - |
dc.identifier.scopusid | 2-s2.0-85029044916 | - |
dc.identifier.wosid | 000414044100011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.10, pp.1616 - 1625 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1616 | - |
dc.citation.endPage | 1625 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002266180 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | BAX | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | CONTRIBUTE | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordAuthor | Ischemia/Reperfusion | - |
dc.subject.keywordAuthor | Neutrophil | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Reverse Transendothelial Migration | - |
dc.subject.keywordAuthor | Recovery | - |
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