IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeon, Seung-min | - |
dc.contributor.author | Halim, Lea | - |
dc.contributor.author | Chandele, Anmol | - |
dc.contributor.author | Perry, Curtis J. | - |
dc.contributor.author | Kim, Sang Hoon | - |
dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Yuk, Soon Hong | - |
dc.contributor.author | Kaech, Susan M. | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.date.accessioned | 2021-09-03T01:49:15Z | - |
dc.date.available | 2021-09-03T01:49:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-09-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82247 | - |
dc.description.abstract | Memory T cells respond rapidly to repeated antigen exposure and can maintain their population for extended periods through self-renewal. These characteristics of memory T cells have mainly been studied during viral infections, whereas their existence and functions in allergic diseases have been studied incompletely. Since allergic patients can suffer repeated relapses caused by intermittent allergen exposure, we hypothesized that allergen-specific memory Th2 cells are present and the factors necessary for the maintenance of these cells are provided by the lung and airways. Using a murine model of airway inflammation, we found that allergen-specific CD4 T cells survived longer than 70 days in the lung and airways in an IL-7 dependent fashion. These T cells showing homeostatic proliferation were largely found in the mediastinal lymph node (mLN), rather than the airways; however, cells residing in the lung and airways developed recall responses successfully. We also found that CD4 T cells exhibited differential phenotypes in the mLN and in the lung. Altogether, we believe that allergenspecific memory T cells reside and function in the lung and airways, while their numbers are replenished through homeostatic turnover in the mLNs. Furthermore, we determined that IL-7 signaling is important for the homeostasis of these cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | HOUSE-DUST MITE | - |
dc.subject | NONLYMPHOID TISSUES | - |
dc.subject | BRONCHOALVEOLAR LAVAGE | - |
dc.subject | T-HELPER-2 CELLS | - |
dc.subject | CUTTING EDGE | - |
dc.subject | ANTIGEN | - |
dc.subject | VIRUS | - |
dc.subject | RESIDENT | - |
dc.subject | MAINTENANCE | - |
dc.subject | PHENOTYPE | - |
dc.title | IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.1038/s41598-017-11492-7 | - |
dc.identifier.scopusid | 2-s2.0-85029284989 | - |
dc.identifier.wosid | 000410063400084 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | HOUSE-DUST MITE | - |
dc.subject.keywordPlus | NONLYMPHOID TISSUES | - |
dc.subject.keywordPlus | BRONCHOALVEOLAR LAVAGE | - |
dc.subject.keywordPlus | T-HELPER-2 CELLS | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | RESIDENT | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | PHENOTYPE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.