Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma: results of a multi-institutional comprehensive study
DC Field | Value | Language |
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dc.contributor.author | Ha, Yun-Sok | - |
dc.contributor.author | Chung, Jae-Wook | - |
dc.contributor.author | Chun, So Young | - |
dc.contributor.author | Choi, Seock Hwan | - |
dc.contributor.author | Lee, Jun Nyung | - |
dc.contributor.author | Kim, Bum Soo | - |
dc.contributor.author | Kim, Hyun Tae | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Kim, Yong-June | - |
dc.contributor.author | Kwon, Tae Gyun | - |
dc.date.accessioned | 2021-09-03T01:50:09Z | - |
dc.date.available | 2021-09-03T01:50:09Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-09-08 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82252 | - |
dc.description.abstract | Background: The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort. Methods: A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count >= 400,000/mu L. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups. Results: Out of the 4,376 patients in the study, 106 (2.4%) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrence-free survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS. Conclusions: TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.subject | PLATELET COUNT | - |
dc.subject | POOR-PROGNOSIS | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | CLINICAL-SIGNIFICANCE | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | BREAST-CANCER | - |
dc.subject | SURVIVAL | - |
dc.subject | NEPHRECTOMY | - |
dc.subject | METASTASIS | - |
dc.subject | VEGF | - |
dc.title | Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma: results of a multi-institutional comprehensive study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.18632/oncotarget.16136 | - |
dc.identifier.scopusid | 2-s2.0-85029911388 | - |
dc.identifier.wosid | 000410284800135 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.8, no.38, pp.64449 - 64458 | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 8 | - |
dc.citation.number | 38 | - |
dc.citation.startPage | 64449 | - |
dc.citation.endPage | 64458 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | PLATELET COUNT | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | NEPHRECTOMY | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordAuthor | renal cell carcinoma | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | thrombocytosis | - |
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