Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses
DC Field | Value | Language |
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dc.contributor.author | Park, Hyun Jung | - |
dc.contributor.author | Lee, Sung Won | - |
dc.contributor.author | Kwon, Dong-Joo | - |
dc.contributor.author | Heo, Seong-Il | - |
dc.contributor.author | Park, Se-Ho | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Hong, Seokmann | - |
dc.date.accessioned | 2021-09-03T01:52:19Z | - |
dc.date.available | 2021-09-03T01:52:19Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-09-06 | - |
dc.identifier.issn | 1472-6882 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82263 | - |
dc.description.abstract | Background: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that are mediated by pathogenic Th1 and Th17 cells. Previous studies have demonstrated that taheebo water extract (TWE) derived from Tabebuia avellanedae Lorentz ex Griseb., as folk remedy, has been used to treat various inflammatory diseases. Although TWE has been previously shown to display anti-inflammatory activities, the in vivo effects of TWE on mucosal immune responses remain unclear. Methods: We examined the anti-inflammatory effects of TWE on innate immune cells such as dendritic cells (DCs) and macrophages and also on the differentiation of T helper cells. Lastly, adopting a method for dextran sulfate sodium (DSS)-induced colitis, we investigated whether the oral administration of TWE can modulate mucosal inflammatory responses. Results: We found that TWE could activate DCs to produce immunosuppressive IL10 and polarize macrophages toward an anti-inflammatory phenotype in the mesenteric lymph node (MLN). Such alterations in DCs and macrophages resulted in a significant increase in anti-inflammatory Th2 and Foxp3(+) Treg cells and a dramatic decrease in pro-inflammatory Th1 and Th17 cells in the MLN. Upon induction of colitis with DSS treatment, TWE significantly reduced the clinical symptoms, including body weight loss and colonic tissue inflammation, by up-regulating type II T helper immune responses. Conclusions: Taken together, these data suggest that TWE is an excellent natural product with therapeutic effects to help improve inflammatory disorders such as colitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | INNER BARK | - |
dc.subject | INTESTINAL MACROPHAGES | - |
dc.subject | CITROBACTER-RODENTIUM | - |
dc.subject | M2-LIKE MACROPHAGES | - |
dc.subject | AMELIORATES COLITIS | - |
dc.subject | ETHANOLIC EXTRACT | - |
dc.subject | POLARIZING M1 | - |
dc.subject | INFLAMMATION | - |
dc.subject | NAPHTHOQUINONE | - |
dc.title | Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.1186/s12906-017-1952-4 | - |
dc.identifier.scopusid | 2-s2.0-85028939892 | - |
dc.identifier.wosid | 000409200500003 | - |
dc.identifier.bibliographicCitation | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.17 | - |
dc.relation.isPartOf | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.title | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INNER BARK | - |
dc.subject.keywordPlus | INTESTINAL MACROPHAGES | - |
dc.subject.keywordPlus | CITROBACTER-RODENTIUM | - |
dc.subject.keywordPlus | M2-LIKE MACROPHAGES | - |
dc.subject.keywordPlus | AMELIORATES COLITIS | - |
dc.subject.keywordPlus | ETHANOLIC EXTRACT | - |
dc.subject.keywordPlus | POLARIZING M1 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | NAPHTHOQUINONE | - |
dc.subject.keywordAuthor | Taheebo water extract | - |
dc.subject.keywordAuthor | Dextran sulfate sodium | - |
dc.subject.keywordAuthor | Intestinal inflammation | - |
dc.subject.keywordAuthor | M2 macrophage | - |
dc.subject.keywordAuthor | Treg cells | - |
dc.subject.keywordAuthor | Th2 cells | - |
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