Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ji Seong | - |
dc.contributor.author | Nam, Ki Taek | - |
dc.contributor.author | Lee, Buhyun | - |
dc.contributor.author | Pamungkas, Aryo Dimas | - |
dc.contributor.author | Song, Daeun | - |
dc.contributor.author | Kim, Minjeong | - |
dc.contributor.author | Yu, Wook-Joon | - |
dc.contributor.author | Lee, Jinsoo | - |
dc.contributor.author | Jee, Sunha | - |
dc.contributor.author | Park, Youngja H. | - |
dc.contributor.author | Lim, Kyung-Min | - |
dc.date.accessioned | 2021-09-03T01:56:25Z | - |
dc.date.available | 2021-09-03T01:56:25Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82289 | - |
dc.description.abstract | Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett's test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in C-max, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in C-max and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.subject | SPRAGUE-DAWLEY RATS | - |
dc.subject | PLASMA-CONCENTRATIONS | - |
dc.subject | ETHINYL ESTRADIOL | - |
dc.subject | ORAL-EXPOSURE | - |
dc.subject | HUMAN URINE | - |
dc.subject | IN-VITRO | - |
dc.subject | EXPRESSION | - |
dc.subject | ESTROGEN | - |
dc.subject | RECEPTOR | - |
dc.subject | MICE | - |
dc.title | Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Youngja H. | - |
dc.identifier.doi | 10.4062/biomolther.2017.148 | - |
dc.identifier.scopusid | 2-s2.0-85029152393 | - |
dc.identifier.wosid | 000409152400011 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.25, no.5, pp.545 - 552 | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 545 | - |
dc.citation.endPage | 552 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002258268 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SPRAGUE-DAWLEY RATS | - |
dc.subject.keywordPlus | PLASMA-CONCENTRATIONS | - |
dc.subject.keywordPlus | ETHINYL ESTRADIOL | - |
dc.subject.keywordPlus | ORAL-EXPOSURE | - |
dc.subject.keywordPlus | HUMAN URINE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Bisphenol A | - |
dc.subject.keywordAuthor | Toxicokinetics | - |
dc.subject.keywordAuthor | Bile duct proliferation | - |
dc.subject.keywordAuthor | Juvenile animals | - |
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