Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Yongcheol | - |
dc.contributor.author | Park, Dongeun | - |
dc.contributor.author | Kim, Chungho | - |
dc.date.accessioned | 2021-09-03T02:51:53Z | - |
dc.date.available | 2021-09-03T02:51:53Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-08-26 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82525 | - |
dc.description.abstract | Ectodomain shedding regulates functions of many membrane proteins through the cleavage of their juxtamembrane region mainly by a disintegrin and metalloproteinase family proteinases. Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)induced shedding of various membrane proteins. How PMA regulates TACE-dependent shedding and how TACE exhibits substrate specificity without proteolysis of other membrane proteins are questionable. Here, we show that TACE can interact with an actin-binding protein, filamin, through 20th filamin repeat. We found that the interaction between TACE and filamin was increased by PMA treatment. In addition, loss of filamin or specific disruption of TACE-filamin interaction inhibited ectodomain shedding of representative TACE substrates, CD44 and amyloid protein precursor. From these data, we suggest that filamin may work as a scaffold that can recruit TACE and its substrates in a PMA-dependent manner to achieve substrate specificity for TACE. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | TRANSMEMBRANE SERINE-PROTEASE | - |
dc.subject | HEPATOCYTE GROWTH-FACTOR | - |
dc.subject | CONVERTING-ENZYME | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | MATRIPTASE | - |
dc.subject | ACTIVATION | - |
dc.subject | BINDING | - |
dc.subject | DOMAINS | - |
dc.subject | METALLOPROTEINASE | - |
dc.title | Disruption of TACE-filamin interaction can inhibit TACE-mediated ectodomain shedding | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Yongcheol | - |
dc.contributor.affiliatedAuthor | Kim, Chungho | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.06.153 | - |
dc.identifier.scopusid | 2-s2.0-85021305468 | - |
dc.identifier.wosid | 000406820600062 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.490, no.3, pp.997 - 1003 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 490 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 997 | - |
dc.citation.endPage | 1003 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | TRANSMEMBRANE SERINE-PROTEASE | - |
dc.subject.keywordPlus | HEPATOCYTE GROWTH-FACTOR | - |
dc.subject.keywordPlus | CONVERTING-ENZYME | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | MATRIPTASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DOMAINS | - |
dc.subject.keywordPlus | METALLOPROTEINASE | - |
dc.subject.keywordAuthor | Filamin | - |
dc.subject.keywordAuthor | TACE | - |
dc.subject.keywordAuthor | Epithin | - |
dc.subject.keywordAuthor | PMA | - |
dc.subject.keywordAuthor | Ectodomain shedding | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.