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Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model

Authors
Lee, Jae YongKim, Sung EunYun, Young-PilChoi, Sung-WookJeon, Daniel I.Kim, Hak-JunPark, KyeongsoonSong, Hae-Ryong
Issue Date
25-8월-2017
Publisher
ELSEVIER SCIENCE INC
Keywords
Alendronate (Aln); Porous PLGA microspheres (PMSs); Rabbit adipose-derived stem cells (rADSCs); Calvarial defect model; Bone regeneration
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.52, pp.277 - 286
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume
52
Start Page
277
End Page
286
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/82533
DOI
10.1016/j.jiec.2017.03.057
ISSN
1226-086X
Abstract
In this study, we evaluated in vitro osteogenic differentiation and in vivo new bone formation using the alendronate-releasing porous PLGA microsphere (Aln/PMS) system in rats with a critical-sized calvarial defect. Aln/PMS system significantly enhanced in vitro osteogenic differentiation and maturation, showing significantly enhanced ALP activity, calcium deposition and the expression of osteocalcin and osteopontin, relative to PMS alone. Also, micro-CT analyses and histology results suggested that Aln/PMS system increased mineralization and bone matrix formation compared to PMS alone. This study demonstrated that the local delivery of Aln, a potent-osteoinductive factor, significantly enhances rabbit adipose-derived stem cells osteogenesis and bone regeneration. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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