Osteogenic Potential of Non Thermal Biocompatible Atmospheric Pressure Plasma Treated Zirconia: In Vitro Study
- Authors
- Jha, Nayansi; Choi, Jin Sung; Kim, Ji Hye; Jung, Ranju; Choi, Eun Ha; Ryu, Jae Jun; Han, Ihn
- Issue Date
- 8월-2017
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Dental Implants; Osseointegration; YTZP (Yttria Stabilized Tetragonal Zirconia); Non-Thermal Biocompatible Atmospheric Plasma (NBP); Dielectric Barrier Discharge (DBD); MC3T3-E1 Osteoblasts
- Citation
- JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, v.7, no.8, pp.662 - 670
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
- Volume
- 7
- Number
- 8
- Start Page
- 662
- End Page
- 670
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82612
- DOI
- 10.1166/jbt.2017.1626
- ISSN
- 2157-9083
- Abstract
- Zirconia has recently gained importance as a dental implant material due to its favourable properties. The present study aimed to evaluate the osteogenic potential of Non Thermal Atmospheric Pressure Plasma treated YTZP using O-2 and N-2 gases. The proliferation and differentiation of osteoblastic cell-line MC3T3-E1 was tested using dielectric barrier discharge plasma as a new technique. YTZP discs were divided into control (untreated) and plasma (O-2 or N-2) treated groups on which MC3T3-E1 osteoblastic cells were seeded. The specimens were tested for cell cytotoxicity and differentiation and surface characteristics were analysed using scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), Energy dispersive X-ray spectroscopy (EDS) and contact angle analysis. Surface analysis indicated generation of zirconium oxide nanoparticles on the discs and the contact angle decreased slightly on treatment with O-2 and N-2 gas. XPS and EDS analysis revealed the structural effects on YTZP surface due to plasma treatment. Alizarin Red Staining indicated increased osteogenic response on plasma coated YTZP discs (N-2Effect > O-2Effect). The overall effect of plasma surface treatment was positive for MC3T3-E1 osteoblasts. The results suggest that plasma treatment improves the YTZP surface and is favourable for osteogenesis.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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