Disrupted functional connectome in antisocial personality disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jiang, Weixiong | - |
dc.contributor.author | Shi, Feng | - |
dc.contributor.author | Liao, Jian | - |
dc.contributor.author | Liu, Huasheng | - |
dc.contributor.author | Wang, Tao | - |
dc.contributor.author | Shen, Celina | - |
dc.contributor.author | Shen, Hui | - |
dc.contributor.author | Hu, Dewen | - |
dc.contributor.author | Wang, Wei | - |
dc.contributor.author | Shen, Dinggang | - |
dc.date.accessioned | 2021-09-03T03:20:04Z | - |
dc.date.available | 2021-09-03T03:20:04Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1931-7557 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82644 | - |
dc.description.abstract | Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | FRONTOPARIETAL CONTROL-SYSTEM | - |
dc.subject | LIFE-COURSE-PERSISTENT | - |
dc.subject | FRONTAL-LOBE | - |
dc.subject | SMALL-WORLD | - |
dc.subject | MODULAR ORGANIZATION | - |
dc.subject | EXECUTIVE FUNCTION | - |
dc.subject | PREFRONTAL CORTEX | - |
dc.subject | SERIOUSLY VIOLENT | - |
dc.subject | TEMPORAL GYRUS | - |
dc.subject | GLOBAL SIGNAL | - |
dc.title | Disrupted functional connectome in antisocial personality disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shen, Dinggang | - |
dc.identifier.doi | 10.1007/s11682-016-9572-z | - |
dc.identifier.scopusid | 2-s2.0-84982286521 | - |
dc.identifier.wosid | 000407840500015 | - |
dc.identifier.bibliographicCitation | BRAIN IMAGING AND BEHAVIOR, v.11, no.4, pp.1071 - 1084 | - |
dc.relation.isPartOf | BRAIN IMAGING AND BEHAVIOR | - |
dc.citation.title | BRAIN IMAGING AND BEHAVIOR | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1071 | - |
dc.citation.endPage | 1084 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.subject.keywordPlus | FRONTOPARIETAL CONTROL-SYSTEM | - |
dc.subject.keywordPlus | LIFE-COURSE-PERSISTENT | - |
dc.subject.keywordPlus | FRONTAL-LOBE | - |
dc.subject.keywordPlus | SMALL-WORLD | - |
dc.subject.keywordPlus | MODULAR ORGANIZATION | - |
dc.subject.keywordPlus | EXECUTIVE FUNCTION | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | SERIOUSLY VIOLENT | - |
dc.subject.keywordPlus | TEMPORAL GYRUS | - |
dc.subject.keywordPlus | GLOBAL SIGNAL | - |
dc.subject.keywordAuthor | Antisocial personality disorder | - |
dc.subject.keywordAuthor | Brain connectome | - |
dc.subject.keywordAuthor | Topological organization | - |
dc.subject.keywordAuthor | Modularity | - |
dc.subject.keywordAuthor | Functional connectivity | - |
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