Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-09-03T03:21:39Z | - |
dc.date.available | 2021-09-03T03:21:39Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0032-5473 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82653 | - |
dc.description.abstract | Objectives To systematically review evidence regarding the relationship between circulating interleukin-17 (IL-17) levels and rheumatoid arthritis (RA), and associations between polymorphisms in IL-17 genes and RA susceptibility. Method We performed a meta-analysis of serum/plasma IL-17 levels in patients with RA and controls, and evaluated evidence of associations between the rs2275913, rs3819024, rs4711998 and rs8193036 polymorphisms in IL-17A and the rs763780 and rs2397084 polymorphisms in IL-17F and risk for RA. Results Fourteen studies including 3118 patients with RA and 2725 controls were included. Our meta-analysis revealed that IL-17 levels were significantly higher in the RA group than in the control group (p=3.1x10(-6)). Subgroup analysis using sample size showed increased IL-17 levels in samples from both small (n <= 100) and large (n>100) RA groups (p=1.1x10(-4) and p=0.008, respectively). We found evidence of associations between RA and alleles from the IL-17A rs2275913 and IL-17F rs763780 polymorphisms in Caucasians (p=0.003 and p=0.037, respectively). In addition, we found an association between RA and alleles of the IL-17A rs3819024 polymorphism in the pooled RA cohort compared with matched controls (p=0.033). However, no evidence of association was found between the IL-17F rs2397084, IL-17A rs4711998 and IL-17A rs8193036 polymorphisms and RA susceptibility. Conclusions Our meta-analysis revealed significantly higher circulating IL-17 levels in patients with RA, and found evidence of associations between the IL-17A rs2275913, IL-17F rs763780 and IL-17A rs3819024 polymorphisms and pathogenesis of RA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.subject | INFLAMMATORY CYTOKINES | - |
dc.subject | SERUM-LEVELS | - |
dc.subject | T-CELLS | - |
dc.subject | INTERLEUKIN-17 | - |
dc.subject | MECHANISMS | - |
dc.subject | INDUCTION | - |
dc.subject | ASTHMA | - |
dc.subject | GAMMA | - |
dc.title | Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1136/postgradmedj-2016-134637 | - |
dc.identifier.scopusid | 2-s2.0-85026645331 | - |
dc.identifier.wosid | 000406740000005 | - |
dc.identifier.bibliographicCitation | POSTGRADUATE MEDICAL JOURNAL, v.93, no.1102, pp.465 - 471 | - |
dc.relation.isPartOf | POSTGRADUATE MEDICAL JOURNAL | - |
dc.citation.title | POSTGRADUATE MEDICAL JOURNAL | - |
dc.citation.volume | 93 | - |
dc.citation.number | 1102 | - |
dc.citation.startPage | 465 | - |
dc.citation.endPage | 471 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | SERUM-LEVELS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | INTERLEUKIN-17 | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | GAMMA | - |
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