Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss: A meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Jae Hyun | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.date.accessioned | 2021-09-03T03:29:01Z | - |
dc.date.available | 2021-09-03T03:29:01Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82696 | - |
dc.description.abstract | Objective: Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design: We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published liteiature from PubMed and Embase. Results: We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR=0.71, 95% CI = 0.51-0.99, P=0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52-0.98, P=0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR=0.53, 0 = 0.33-0.85, P=0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion: Our meta-analysis supports an association between F13A1 Val34Leu and RPL. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | COAGULATION-FACTOR-XIII | - |
dc.subject | THROMBOPHILIC GENE-MUTATIONS | - |
dc.subject | SPONTANEOUS-ABORTION | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | CLOT STRUCTURE | - |
dc.subject | MISCARRIAGE | - |
dc.subject | RISK | - |
dc.subject | WOMEN | - |
dc.subject | SUBUNIT | - |
dc.subject | HETEROGENEITY | - |
dc.title | Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.identifier.doi | 10.1016/j.ejogrb.2017.06.032 | - |
dc.identifier.scopusid | 2-s2.0-85021672818 | - |
dc.identifier.wosid | 000407183300038 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.215, pp.234 - 240 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.citation.volume | 215 | - |
dc.citation.startPage | 234 | - |
dc.citation.endPage | 240 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | COAGULATION-FACTOR-XIII | - |
dc.subject.keywordPlus | THROMBOPHILIC GENE-MUTATIONS | - |
dc.subject.keywordPlus | SPONTANEOUS-ABORTION | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | CLOT STRUCTURE | - |
dc.subject.keywordPlus | MISCARRIAGE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | SUBUNIT | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordAuthor | Recurrent pregnancy loss | - |
dc.subject.keywordAuthor | F13AI Val34Leu | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.