Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction
DC Field | Value | Language |
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dc.contributor.author | Yu, Dong-Min | - |
dc.contributor.author | Jung, Seung Hee | - |
dc.contributor.author | An, Hyoung-Tae | - |
dc.contributor.author | Lee, Sungsoo | - |
dc.contributor.author | Hong, Jin | - |
dc.contributor.author | Park, Jun Sub | - |
dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Lee, Hwayeon | - |
dc.contributor.author | Bahn, Myeong-Suk | - |
dc.contributor.author | Lee, Hyung Chul | - |
dc.contributor.author | Han, Na-Kyung | - |
dc.contributor.author | Ko, Jesang | - |
dc.contributor.author | Lee, Jae-Seon | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.date.accessioned | 2021-09-03T03:31:15Z | - |
dc.date.available | 2021-09-03T03:31:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82707 | - |
dc.description.abstract | Paradoxical observations have been made regarding the role of cayeolin-1 (Cav-1) during cellular senescence. For example, caveolin-1 deficiency prevents reactive oxygen species-induced cellular senescence despite mitochondrial dysfunction, which leads to senescence. To resolve this paradox, we re addressed the role of caveolin-1 in cellular senescence in human diploid fibroblasts, A549, HCT116, and Cay-1(-/-) mouse embryonic fibroblasts. Cav-1 deficiency (knockout or knockdown) induced cellular senescence via a p53-p21-dependent pathway, downregulating the expression level of the cardiolipin biosynthesis enzymes and then reducing the content of cardiolipin, a critical lipid for mitochondria! respiration. Our results showed that Cav-1 deficiency decreased mitochondrial respiration, reduced the activity of oxidative phosphorylation complex I (CI), inactivated SIRT1, and decreased the NAD(+)/NADH ratio. From these results, we concluded that Cav-1 deficiency induces premature senescence via mitochondrial dysfunction and silent information regulator 2 homologue 1 (SIRT1) inactivation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ONCOGENE-INDUCED SENESCENCE | - |
dc.subject | CELLULAR SENESCENCE | - |
dc.subject | INSULIN SENSITIVITY | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | UP-REGULATION | - |
dc.subject | CELLS | - |
dc.subject | PROTEIN | - |
dc.subject | P53 | - |
dc.subject | FIBROBLASTS | - |
dc.subject | CANCER | - |
dc.title | Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sungsoo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.1111/acel.12606 | - |
dc.identifier.scopusid | 2-s2.0-85019220371 | - |
dc.identifier.wosid | 000405490300017 | - |
dc.identifier.bibliographicCitation | AGING CELL, v.16, no.4, pp.773 - 784 | - |
dc.relation.isPartOf | AGING CELL | - |
dc.citation.title | AGING CELL | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 773 | - |
dc.citation.endPage | 784 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.subject.keywordPlus | ONCOGENE-INDUCED SENESCENCE | - |
dc.subject.keywordPlus | CELLULAR SENESCENCE | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | cardiolipin | - |
dc.subject.keywordAuthor | caveolin-1 | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | senescence | - |
dc.subject.keywordAuthor | SIRT1 | - |
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