A Text-Based Data Mining and Toxicity Prediction Modeling System for a Clinical Decision Support in Radiation Oncology: A Preliminary Study
- Authors
- Kim, Kwang Hyeon; Lee, Suk; Shim, Jang Bo; Chang, Kyung Hwan; Yang, Dae Sik; Yoon, Won Sup; Park, Young Je; Kim, Chul Yong; Cao, Yuan Jie
- Issue Date
- 8월-2017
- Publisher
- KOREAN PHYSICAL SOC
- Keywords
- Data mining; Toxicity prediction; Radiotherapy; Clinical decision support system; Big data
- Citation
- JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.71, no.4, pp.231 - 237
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF THE KOREAN PHYSICAL SOCIETY
- Volume
- 71
- Number
- 4
- Start Page
- 231
- End Page
- 237
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82726
- DOI
- 10.3938/jkps.71.231
- ISSN
- 0374-4884
- Abstract
- The aim of this study is an integrated research for text-based data mining and toxicity prediction modeling system for clinical decision support system based on big data in radiation oncology as a preliminary research. The structured and unstructured data were prepared by treatment plans and the unstructured data were extracted by dose-volume data image pattern recognition of prostate cancer for research articles crawling through the internet. We modeled an artificial neural network to build a predictor model system for toxicity prediction of organs at risk. We used a text-based data mining approach to build the artificial neural network model for bladder and rectum complication predictions. The pattern recognition method was used to mine the unstructured toxicity data for dose-volume at the detection accuracy of 97.9%. The confusion matrix and training model of the neural network were achieved with 50 modeled plans (n = 50) for validation. The toxicity level was analyzed and the risk factors for 25% bladder, 50% bladder, 20% rectum, and 50% rectum were calculated by the artificial neural network algorithm. As a result, 32 plans could cause complication but 18 plans were designed as non-complication among 50 modeled plans. We integrated data mining and a toxicity modeling method for toxicity prediction using prostate cancer cases. It is shown that a preprocessing analysis using text-based data mining and prediction modeling can be expanded to personalized patient treatment decision support based on big data.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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