MST1 deficiency promotes B cell responses by CD4(+) T cell-derived IL-4, resulting in hypergammaglobulinemia
DC Field | Value | Language |
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dc.contributor.author | Park, Eunchong | - |
dc.contributor.author | Kim, Myun Soo | - |
dc.contributor.author | Song, Ju Han | - |
dc.contributor.author | Roh, Kyung-Hye | - |
dc.contributor.author | Lee, Rana | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-03T03:58:18Z | - |
dc.date.available | 2021-09-03T03:58:18Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07-15 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82825 | - |
dc.description.abstract | MST1 deficiency causes T and B cell lymphopenia, resulting in combined immunodeficiency. However, MST1-deficient patients also exhibit autoimmune-like symptoms such as hypergammaglobulinemia and autoantibody production. Recent studies have shown that the autoimmune responses observed in MST1-deficient patients were most likely attributable to defective regulatory T (Treg) cells instead of intrinsic signals in MST1-lacking B cells. Nevertheless, it is not determined how MST1 deficiency in T cells breaks B cell tolerance and causes systemic autoimmune-like phenotypes. In this study, we confirmed that Mst1(-/-) mice developed hypergammaglobulinemia associated with increased levels of IgG, IgA, and IgE. We also showed that uncontrolled B cell responses were resulted from the IL-4-rich environment created by CD4(+) T cells. Defective MST1-FOXO1 signaling down-regulated Treg cells, resulting in the collapse of immune tolerance where the populations of Th2 and T follicular helper cells expanded. In conclusion, we suggest that MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | IMMUNODEFICIENCY | - |
dc.subject | PROLIFERATION | - |
dc.subject | STABILITY | - |
dc.title | MST1 deficiency promotes B cell responses by CD4(+) T cell-derived IL-4, resulting in hypergammaglobulinemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.05.094 | - |
dc.identifier.scopusid | 2-s2.0-85019633806 | - |
dc.identifier.wosid | 000403855600009 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.489, no.1, pp.56 - 62 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 489 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 62 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | IMMUNODEFICIENCY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordAuthor | MST1 | - |
dc.subject.keywordAuthor | CD4(+) T cell | - |
dc.subject.keywordAuthor | B cell activation | - |
dc.subject.keywordAuthor | IL-4 | - |
dc.subject.keywordAuthor | CD40L | - |
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