Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Ka Young | - |
dc.contributor.author | Lee, Hui Su | - |
dc.contributor.author | Seol, Geun Hee | - |
dc.date.accessioned | 2021-09-03T04:22:02Z | - |
dc.date.available | 2021-09-03T04:22:02Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82922 | - |
dc.description.abstract | Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that is generally characterized by progressive and irreversible airflow obstruction and alveolar destruction. Long-term treatment with current medications has been associated with various adverse effects, indicating a need for alternative approaches for the prevention and treatment of COPD. This study investigated the mechanism underlying the effects of trans-anethole in a mouse model of COPD induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS). BALB/c mice were orally administered trans-anethole (62.5, 125, 250, or 500 mg/kg) 2 h before intranasal challenge with 1.2 units of PPE and 7 mu g of LPS. Lactate dehydrogenase (LDH) activity, cell counts, lung histology, cytokine production, and blood pressure were analyzed. Trans-anethole reduced LDH activity and inflammatory cell counts, including macrophage, neutrophil, and lymphocyte counts. trans-anethole 125 mg/kg restored the histopathological changes induced in mouse lungs by PPE and LPS. trans-anethole reduced the serum concentrations of pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), as well as significantly reducing blood pressure during chronic inflammation. Trans-anethole ameliorated chronic lung inflammation in a mouse model of COPD by reducing the serum concentrations of pro-inflammatory cytokines such as TNF-alpha and IL-6, and by reducing blood pressure. The present results indicate that trans-anethole may be a potential therapeutic agent for prophylaxis and treatment in patients with chronic lung inflammation. (C) 2017 Elsevier Masson SAS. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | ACUTE LUNG INJURY | - |
dc.subject | KAPPA-B | - |
dc.subject | COPD | - |
dc.subject | INFLAMMATION | - |
dc.subject | MANIFESTATIONS | - |
dc.subject | DITHIOLETHIONE | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | EMPHYSEMA | - |
dc.subject | RESPONSES | - |
dc.subject | FEATURES | - |
dc.title | Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seol, Geun Hee | - |
dc.identifier.doi | 10.1016/j.biopha.2017.05.032 | - |
dc.identifier.scopusid | 2-s2.0-85019224448 | - |
dc.identifier.wosid | 000406399900103 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, v.91, pp.925 - 930 | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.title | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.volume | 91 | - |
dc.citation.startPage | 925 | - |
dc.citation.endPage | 930 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ACUTE LUNG INJURY | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MANIFESTATIONS | - |
dc.subject.keywordPlus | DITHIOLETHIONE | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | EMPHYSEMA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | Trans-anethole | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease (COPD) | - |
dc.subject.keywordAuthor | Interleukin-6 (IL-6) | - |
dc.subject.keywordAuthor | Blood pressure | - |
dc.subject.keywordAuthor | Porcine pancreatic elastase (PPE) | - |
dc.subject.keywordAuthor | Lipopolysaccharide (LPS) | - |
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