Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong Hyun | - |
dc.contributor.author | Kim, Jee Yong | - |
dc.contributor.author | Yoo, Chang Hoon | - |
dc.contributor.author | Seo, Won Hee | - |
dc.contributor.author | Yoo, Young | - |
dc.contributor.author | Song, Dae Jin | - |
dc.contributor.author | Choung, Ji Tae | - |
dc.date.accessioned | 2021-09-03T04:25:12Z | - |
dc.date.available | 2021-09-03T04:25:12Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82941 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate the change in macrolide resistance rate in pediatric Mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant M. pneumoniae (MRMP) on the clinical course of disease, by comparing 2 recent, consecutive epidemics in Korea. Methods: A total of 250 patients with M. pneumoniae pneumonia admitted to a single tertiary hospital were enrolled in this study. Detection of MRMP was based on specific point mutations in domain V of the 23S rRNA gene. The medical records of enrolled patients were reviewed retrospectively, and the clinical courses and laboratory data were compared. Results: The macrolide resistance rate of M. pneumoniae was 51.1% (48/94) in the 2011 epidemic, and 87.2% (136/156) in the 2015 epidemic. All MRMP isolates had the A2063G point mutation. In comparison of 2 epidemics, the mean age of patients with M pneumoniae pneumonia was increased, and the total febrile days and febrile days after initiation of macrolides were prolonged in the 2015 epidemic. Overall severity of MRMP or macrolide-susceptible M. pneumoniae (MSMP) pneumonia over 2 epidemics was not significantly changed. However, the proportion of patients who had a fever lasting more than 72 hours after initiation of macrolides and who received corticosteroid treatment were higher in MRMP pneumonia during 2 epidemics. Conclusions: The macrolide resistance rate of M pneumoniae has risen rapidly over 2 recent, consecutive epidemics, and this has been associated with a prolonged clinical course and increased use of corticosteroids to treat pediatric M. pneumoniae pneumonia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.subject | COMMUNITY-ACQUIRED PNEUMONIA | - |
dc.subject | RESPIRATORY-TRACT INFECTIONS | - |
dc.subject | MYCOPLASMA-PNEUMONIAE | - |
dc.subject | PEDIATRIC-PATIENTS | - |
dc.subject | PREDNISOLONE | - |
dc.subject | THERAPY | - |
dc.subject | CHINA | - |
dc.title | Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Won Hee | - |
dc.contributor.affiliatedAuthor | Yoo, Young | - |
dc.contributor.affiliatedAuthor | Song, Dae Jin | - |
dc.contributor.affiliatedAuthor | Choung, Ji Tae | - |
dc.identifier.doi | 10.4168/aair.2017.9.4.340 | - |
dc.identifier.scopusid | 2-s2.0-85019209285 | - |
dc.identifier.wosid | 000404835300008 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.9, no.4, pp.340 - 346 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 340 | - |
dc.citation.endPage | 346 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002242340 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | COMMUNITY-ACQUIRED PNEUMONIA | - |
dc.subject.keywordPlus | RESPIRATORY-TRACT INFECTIONS | - |
dc.subject.keywordPlus | MYCOPLASMA-PNEUMONIAE | - |
dc.subject.keywordPlus | PEDIATRIC-PATIENTS | - |
dc.subject.keywordPlus | PREDNISOLONE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CHINA | - |
dc.subject.keywordAuthor | Drug resistance | - |
dc.subject.keywordAuthor | macrolides | - |
dc.subject.keywordAuthor | Mycoplasma pneumoniae | - |
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