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Changes in subcortical shape and cognitive function in patients with chronic insomnia

Authors
Koo, Dae LimShin, Jeong-HyeonLim, Jae-SungSeong, Joon-KyungJoo, Eun Yeon
Issue Date
7월-2017
Publisher
ELSEVIER SCIENCE BV
Keywords
Chronic insomnia; Shape analysis; Cognitive function
Citation
SLEEP MEDICINE, v.35, pp.23 - 26
Indexed
SCIE
SCOPUS
Journal Title
SLEEP MEDICINE
Volume
35
Start Page
23
End Page
26
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/82973
DOI
10.1016/j.sleep.2017.04.002
ISSN
1389-9457
Abstract
Objective: The aim of this study was to examine morphological changes in subcortical structures via surface-based analysis and to correlate local shape changes with cognitive function. Methods: We analyzed subcortical brain morphology and compared the shape changes with clinical and neuropsychological features in patients with chronic insomnia. Results: Hippocampal atrophy was associated with higher Pittsburgh Sleep Quality Index scores (r = -0.4, p = 0.0408) and higher arousal indices (r = -0.4, p = 0.0332). Local volume loss of the putamen was associated with higher arousal indices (r = -0.5, p = 0.0416). Atrophic change of subcortical structures including the hippocampus, amygdala, basal ganglia, and thalamus, correlated negatively with verbal fluency, frontal function, verbal memory, and visual memory, respectively, in these patients arl >= 0.3, p < 0.05). Conclusions: This study shows that sleep quality and fragmentation are closely related to atrophic changes in hippocampus and putamen. In addition, atrophic changes in global subcortical structures are associated with impaired cognitive function in patients with chronic insomnia. (C) 2017 Published by Elsevier B.V.
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