End-Terminal Capping Effect on Mechanical Property of Transthyretin (TTR105-115) Amyloid Fibril
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hyunsung | - |
dc.contributor.author | Lee, Myeongsang | - |
dc.contributor.author | Na, Sungsoo | - |
dc.date.accessioned | 2021-09-03T04:40:16Z | - |
dc.date.available | 2021-09-03T04:40:16Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1226-4873 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83032 | - |
dc.description.abstract | The understanding of the mechanical properties of amyloid fibers, which induce various neurodegenerative diseases, is directly related to the amyloid growth mechanism. Diverse studies have been performed on amyloid fibers from the viewpoint of disease epidemiology. Recently, attempts have been made to use amyloid fibers as new materials because of their notable mechanical properties and self-aggregation abilities. In this study, the mechanical properties of transthyretin (TTR105-115), which induces cardiovascular disease, were evaluated using a molecular dynamics (MD) simulation. In particular, the effect of the end-terminal capping on the structural stability of TTR105-115 was evaluated. The mechanical behavior and properties of TTR105-115 were measured by steered molecular dynamics (SMD). We clarified the factors affecting the mechanical properties of these materials and suggested the possibility of utilizing them as nature inspired materials. | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.publisher | KOREAN SOC MECHANICAL ENGINEERS | - |
dc.subject | MOLECULAR-DYNAMICS | - |
dc.subject | STRUCTURAL CHARACTERISTICS | - |
dc.subject | PEPTIDE | - |
dc.subject | BETA(2)-MICROGLOBULIN | - |
dc.subject | STABILITY | - |
dc.subject | OLIGOMERS | - |
dc.subject | RESIDUES | - |
dc.title | End-Terminal Capping Effect on Mechanical Property of Transthyretin (TTR105-115) Amyloid Fibril | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.3795/KSME-A.2017.41.7.621 | - |
dc.identifier.scopusid | 2-s2.0-85027894268 | - |
dc.identifier.wosid | 000410918700007 | - |
dc.identifier.bibliographicCitation | TRANSACTIONS OF THE KOREAN SOCIETY OF MECHANICAL ENGINEERS A, v.41, no.7, pp.621 - 627 | - |
dc.relation.isPartOf | TRANSACTIONS OF THE KOREAN SOCIETY OF MECHANICAL ENGINEERS A | - |
dc.citation.title | TRANSACTIONS OF THE KOREAN SOCIETY OF MECHANICAL ENGINEERS A | - |
dc.citation.volume | 41 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 621 | - |
dc.citation.endPage | 627 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002232133 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Mechanical | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | STRUCTURAL CHARACTERISTICS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | BETA(2)-MICROGLOBULIN | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | OLIGOMERS | - |
dc.subject.keywordPlus | RESIDUES | - |
dc.subject.keywordAuthor | Amyloid Fibril | - |
dc.subject.keywordAuthor | Molecular Dynamics | - |
dc.subject.keywordAuthor | Steered Molecular Dynamics | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.