Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis
DC Field | Value | Language |
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dc.contributor.author | Kitano, Haruhisa | - |
dc.contributor.author | Chung, Joon-Yong | - |
dc.contributor.author | Noh, Kyung Hee | - |
dc.contributor.author | Lee, Young-Ho | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Lee, Seok Hyung | - |
dc.contributor.author | Eo, Soo-Heang | - |
dc.contributor.author | Cho, Hyung Jun | - |
dc.contributor.author | Choi, Chel Hun | - |
dc.contributor.author | Inoue, Shuhei | - |
dc.contributor.author | Hanaoka, Jun | - |
dc.contributor.author | Fukuoka, Junya | - |
dc.contributor.author | Hewitt, Stephen M. | - |
dc.date.accessioned | 2021-09-03T04:55:38Z | - |
dc.date.available | 2021-09-03T04:55:38Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06-17 | - |
dc.identifier.issn | 1479-5876 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83110 | - |
dc.description.abstract | Background: The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear. We aimed to investigate the possible lymphangiogenic significance of synaptonemal complex protein 3 (SCP3) in non-small cell lung cancer (NSCLC). Methods: The expression of SCP3, VEGF-C, and VEGF-D were measured and examined a correlation between SCP3 and VEGF-C or VEGF-D in various human lung cancer cell lines. Subsequently, we assessed SCP3, VEGF-A, VEGF-B, VEGF-C, and VEGF-D expression in archival tumor tissues from 89 NSCLC patients with lymph node (LN) metastasis by combined immunohistochemistry with quantitative digital image analysis. Results: Positive correlations between SCP3 and VEGF-C expression (R-2 = 0.743) and VEGF-D expression (R-2 = 0.932) were detected in various human lung cancer cell lines. The high expression of SCP3, VEGF-A, VEGF-B, VEGF-C, and VEGF-D were detected in 24 (27.0%), 22 (24.7%), 27 (30.3%), 27 (30.3%), and 24 cases (27.0%), respectively. Notably, SCP3 positively correlated with VEGF-C and VEGF-D expression (for both, P < 0.001) and negatively correlated with VEGF-A and VEGF-B expression (P = 0.029 and P = 0.026, respectively). In multivariate analysis of patients with LN metastasis, SCP3 expression predicted worse overall survival (hazard ratio = 1.86, P = 0.008). Conclusions: SCP3 is associated with lymphangiogenesis and provides insight into the SCP3-VEGF-C/VEGF-D axis based cancer therapy strategy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | GROWTH-FACTOR-C | - |
dc.subject | INTERFERING RNA VECTORS | - |
dc.subject | VEGF-C | - |
dc.subject | TUMOR LYMPHANGIOGENESIS | - |
dc.subject | FACTOR RECEPTOR-3 | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | BREAST-CANCER | - |
dc.subject | EXPRESSION | - |
dc.subject | PROMOTES | - |
dc.title | Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Woo | - |
dc.contributor.affiliatedAuthor | Cho, Hyung Jun | - |
dc.identifier.doi | 10.1186/s12967-017-1241-5 | - |
dc.identifier.scopusid | 2-s2.0-85027587245 | - |
dc.identifier.wosid | 000405750400001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TRANSLATIONAL MEDICINE, v.15 | - |
dc.relation.isPartOf | JOURNAL OF TRANSLATIONAL MEDICINE | - |
dc.citation.title | JOURNAL OF TRANSLATIONAL MEDICINE | - |
dc.citation.volume | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | GROWTH-FACTOR-C | - |
dc.subject.keywordPlus | INTERFERING RNA VECTORS | - |
dc.subject.keywordPlus | VEGF-C | - |
dc.subject.keywordPlus | TUMOR LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | FACTOR RECEPTOR-3 | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordAuthor | SCP3 | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
dc.subject.keywordAuthor | Lymphangiogenesis | - |
dc.subject.keywordAuthor | Lymph node metastasis | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
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