Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics
DC Field | Value | Language |
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dc.contributor.author | Park, Je Won | - |
dc.contributor.author | Nam, Sang-Jip | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.date.accessioned | 2021-09-03T04:59:15Z | - |
dc.date.available | 2021-09-03T04:59:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06-15 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83122 | - |
dc.description.abstract | Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010-2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NATURAL-PRODUCT BIOSYNTHESIS | - |
dc.subject | GLYCOSYLATED DERIVATIVES | - |
dc.subject | STREPTOMYCES-VENEZUELAE | - |
dc.subject | AMINOGLYCOSIDE ANTIBIOTICS | - |
dc.subject | HETEROLOGOUS EXPRESSION | - |
dc.subject | ENGINEERED BIOSYNTHESIS | - |
dc.subject | ANTITUMOR-ACTIVITY | - |
dc.subject | SYNTHETIC BIOLOGY | - |
dc.subject | GENE-CLUSTER | - |
dc.subject | POLYKETIDE SYNTHASES | - |
dc.title | Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Je Won | - |
dc.identifier.doi | 10.1016/j.bcp.2016.10.009 | - |
dc.identifier.scopusid | 2-s2.0-85005784386 | - |
dc.identifier.wosid | 000401684700005 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.134, pp.56 - 73 | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 134 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 73 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NATURAL-PRODUCT BIOSYNTHESIS | - |
dc.subject.keywordPlus | GLYCOSYLATED DERIVATIVES | - |
dc.subject.keywordPlus | STREPTOMYCES-VENEZUELAE | - |
dc.subject.keywordPlus | AMINOGLYCOSIDE ANTIBIOTICS | - |
dc.subject.keywordPlus | HETEROLOGOUS EXPRESSION | - |
dc.subject.keywordPlus | ENGINEERED BIOSYNTHESIS | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | SYNTHETIC BIOLOGY | - |
dc.subject.keywordPlus | GENE-CLUSTER | - |
dc.subject.keywordPlus | POLYKETIDE SYNTHASES | - |
dc.subject.keywordAuthor | Combinatorial biosynthesis | - |
dc.subject.keywordAuthor | Sugar-containing antibiotics | - |
dc.subject.keywordAuthor | Anti-infective and anti-proliferative | - |
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